Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men

S.S. Mohan, Matthew Knuiman, Mark Divitini, Alan James, Arthur Musk, D.J. Handelsman, J. Beilin, Michael Hunter, Bu Yeap

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives

Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestosterone (DHT) and oestradiol (E2) are differentially associated with lung function in men.

Methods

Early-morning serum T, DHT and E2 were assayed using mass spectrometry in 1768 community-dwelling men from Busselton, Western Australia. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured using spirometry. Linear regression models adjusting for age, height, smoking, exercise, body mass index, respiratory conditions and cardiovascular risk factors were used.

Results

Mean age was 50.1 ± 16·8 years. 16·0% were current smokers, 14·1% reported a history of asthma and 2·7% reported chronic obstructive pulmonary disease. Current smokers had higher T compared with never smokers (age-adjusted mean 14·5 vs 13·5 nmol/l, P = 0·002) and higher E2 (65·3 vs 60·1 pmol/l, P = 0·017). In fully adjusted analyses, T was associated with FEV1 (51 ml per 1 SD increase, P <0·001) as was DHT (62 ml, P <0·001), E2 was not (P = 0·926). Similar results were seen for FVC (T: 76 ml, P <0·001; DHT: 65 ml, P <0·001; E2 P = 0·664). Higher DHT was marginally associated with the ratio FEV1/FVC (0·3% per 1 SD increase, P = 0·047).

Conclusions

Both T and DHT were independently associated with higher FEV1 and FVC in predominantly middle-aged community-dwelling men. Androgens may contribute to, or be biomarkers for, better lung function in men. Further research is needed to clarify whether androgens preserve lung function in ageing men.

Original languageEnglish
Pages (from-to)268-276
JournalClinical Endocrinology
Volume83
Issue number2
Early online date5 Mar 2015
DOIs
Publication statusPublished - Aug 2015

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Independent Living
Dihydrotestosterone
Testosterone
Estradiol
Vital Capacity
Forced Expiratory Volume
Lung
Androgens
Serum
Linear Models
Western Australia
Spirometry
Chronic Obstructive Pulmonary Disease
Mass Spectrometry
Body Mass Index
Asthma
Biomarkers
Smoking
Exercise
Mortality

Cite this

@article{5798b1283f67456a903177cb14876dcd,
title = "Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men",
abstract = "Objectives Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestosterone (DHT) and oestradiol (E2) are differentially associated with lung function in men. Methods Early-morning serum T, DHT and E2 were assayed using mass spectrometry in 1768 community-dwelling men from Busselton, Western Australia. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured using spirometry. Linear regression models adjusting for age, height, smoking, exercise, body mass index, respiratory conditions and cardiovascular risk factors were used. Results Mean age was 50.1 ± 16·8 years. 16·0{\%} were current smokers, 14·1{\%} reported a history of asthma and 2·7{\%} reported chronic obstructive pulmonary disease. Current smokers had higher T compared with never smokers (age-adjusted mean 14·5 vs 13·5 nmol/l, P = 0·002) and higher E2 (65·3 vs 60·1 pmol/l, P = 0·017). In fully adjusted analyses, T was associated with FEV1 (51 ml per 1 SD increase, P <0·001) as was DHT (62 ml, P <0·001), E2 was not (P = 0·926). Similar results were seen for FVC (T: 76 ml, P <0·001; DHT: 65 ml, P <0·001; E2 P = 0·664). Higher DHT was marginally associated with the ratio FEV1/FVC (0·3{\%} per 1 SD increase, P = 0·047). Conclusions Both T and DHT were independently associated with higher FEV1 and FVC in predominantly middle-aged community-dwelling men. Androgens may contribute to, or be biomarkers for, better lung function in men. Further research is needed to clarify whether androgens preserve lung function in ageing men.",
author = "S.S. Mohan and Matthew Knuiman and Mark Divitini and Alan James and Arthur Musk and D.J. Handelsman and J. Beilin and Michael Hunter and Bu Yeap",
year = "2015",
month = "8",
doi = "10.1111/cen.12738",
language = "English",
volume = "83",
pages = "268--276",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "John Wiley & Sons",
number = "2",

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TY - JOUR

T1 - Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men

AU - Mohan, S.S.

AU - Knuiman, Matthew

AU - Divitini, Mark

AU - James, Alan

AU - Musk, Arthur

AU - Handelsman, D.J.

AU - Beilin, J.

AU - Hunter, Michael

AU - Yeap, Bu

PY - 2015/8

Y1 - 2015/8

N2 - Objectives Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestosterone (DHT) and oestradiol (E2) are differentially associated with lung function in men. Methods Early-morning serum T, DHT and E2 were assayed using mass spectrometry in 1768 community-dwelling men from Busselton, Western Australia. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured using spirometry. Linear regression models adjusting for age, height, smoking, exercise, body mass index, respiratory conditions and cardiovascular risk factors were used. Results Mean age was 50.1 ± 16·8 years. 16·0% were current smokers, 14·1% reported a history of asthma and 2·7% reported chronic obstructive pulmonary disease. Current smokers had higher T compared with never smokers (age-adjusted mean 14·5 vs 13·5 nmol/l, P = 0·002) and higher E2 (65·3 vs 60·1 pmol/l, P = 0·017). In fully adjusted analyses, T was associated with FEV1 (51 ml per 1 SD increase, P <0·001) as was DHT (62 ml, P <0·001), E2 was not (P = 0·926). Similar results were seen for FVC (T: 76 ml, P <0·001; DHT: 65 ml, P <0·001; E2 P = 0·664). Higher DHT was marginally associated with the ratio FEV1/FVC (0·3% per 1 SD increase, P = 0·047). Conclusions Both T and DHT were independently associated with higher FEV1 and FVC in predominantly middle-aged community-dwelling men. Androgens may contribute to, or be biomarkers for, better lung function in men. Further research is needed to clarify whether androgens preserve lung function in ageing men.

AB - Objectives Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestosterone (DHT) and oestradiol (E2) are differentially associated with lung function in men. Methods Early-morning serum T, DHT and E2 were assayed using mass spectrometry in 1768 community-dwelling men from Busselton, Western Australia. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured using spirometry. Linear regression models adjusting for age, height, smoking, exercise, body mass index, respiratory conditions and cardiovascular risk factors were used. Results Mean age was 50.1 ± 16·8 years. 16·0% were current smokers, 14·1% reported a history of asthma and 2·7% reported chronic obstructive pulmonary disease. Current smokers had higher T compared with never smokers (age-adjusted mean 14·5 vs 13·5 nmol/l, P = 0·002) and higher E2 (65·3 vs 60·1 pmol/l, P = 0·017). In fully adjusted analyses, T was associated with FEV1 (51 ml per 1 SD increase, P <0·001) as was DHT (62 ml, P <0·001), E2 was not (P = 0·926). Similar results were seen for FVC (T: 76 ml, P <0·001; DHT: 65 ml, P <0·001; E2 P = 0·664). Higher DHT was marginally associated with the ratio FEV1/FVC (0·3% per 1 SD increase, P = 0·047). Conclusions Both T and DHT were independently associated with higher FEV1 and FVC in predominantly middle-aged community-dwelling men. Androgens may contribute to, or be biomarkers for, better lung function in men. Further research is needed to clarify whether androgens preserve lung function in ageing men.

U2 - 10.1111/cen.12738

DO - 10.1111/cen.12738

M3 - Article

VL - 83

SP - 268

EP - 276

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 2

ER -