TY - JOUR
T1 - Higher Habitual Dietary Flavonoid Intake Associates With Less Extensive Abdominal Aortic Calcification in a Cohort of Older Women
AU - Parmenter, Benjamin H.
AU - Bondonno, Catherine P.
AU - Murray, Kevin
AU - Schousboe, John T.
AU - Croft, Kevin
AU - Prince, Richard L.
AU - Hodgson, Jonathan M.
AU - Bondonno, Nicola P.
AU - Lewis, Joshua R.
N1 - Funding Information:
B.H. Parmenter is supported by an Australian Government Research Training Program Stipend Scholarship. The salary of C.P. Bondonno is supported by a Royal Perth Hospital Research Foundation “Lawrie Beilin” Career Advancement Fellowship (ID: CAF 127/2020). N.P. Bondonno is funded by a National Health and Medical Research Council Early Career Fellowship (Grant number APP1159914), Australia. J.R. Lewis is funded by a National Heart Foundation Future Leader Fellowship (ID: 102817).
Publisher Copyright:
© 2022 American Heart Association, Inc.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Background: The extent of abdominal aortic calcification (AAC) is a major predictor of vascular disease events. We have previously found regular apple intake, a major source of dietary flavonoids, associates with lower AAC. Whether total dietary flavonoid intake impacts AAC remains unknown. Here, we extend our observations to habitual intakes of total flavonoids, flavonoid subclasses, and specific flavonoid-containing foods, with the odds of extensive AAC. Methods: We conducted cross-sectional analyses on 881 females (median [interquartile range] age, 80 [78-82] years; body mass index, 27 [24-30] kg/m2) from the PLSAW (Perth Longitudinal Study of Ageing Women). Flavonoid intake was calculated from food-frequency questionnaires. Calcifications of the abdominal aorta were assessed on lateral lumbar spine images and categorized as less extensive or extensive. Logistic regression was used to investigate associations. Results: After adjusting for demographic, lifestyle and dietary confounders, participants with higher (Q4), compared with lower (Q1) intakes, of total flavonoids, flavan-3-ols, and flavonols had 36% (odds ratio [95% CI], 0.64 [0.43-0.95]), 39% (0.61 [0.40-0.93]) and 38% (0.62 [0.42-0.92]) lower odds of extensive AAC, respectively. In food-based analyses, higher black tea intake, the main source of total flavonoids (75.9%), associated with significantly lower odds of extensive AAC (2-6 cups/d had 16%-42% lower odds compared with 0 daily intake). In a subset of nonconsumers of black tea, the association of total flavonoid intake with AAC remained (Q4 versus Q1 odds ratio [95% CI], 0.11 [0.02-0.54]). Conclusions: In older women, greater habitual dietary flavonoid intake associates with less extensive AAC.
AB - Background: The extent of abdominal aortic calcification (AAC) is a major predictor of vascular disease events. We have previously found regular apple intake, a major source of dietary flavonoids, associates with lower AAC. Whether total dietary flavonoid intake impacts AAC remains unknown. Here, we extend our observations to habitual intakes of total flavonoids, flavonoid subclasses, and specific flavonoid-containing foods, with the odds of extensive AAC. Methods: We conducted cross-sectional analyses on 881 females (median [interquartile range] age, 80 [78-82] years; body mass index, 27 [24-30] kg/m2) from the PLSAW (Perth Longitudinal Study of Ageing Women). Flavonoid intake was calculated from food-frequency questionnaires. Calcifications of the abdominal aorta were assessed on lateral lumbar spine images and categorized as less extensive or extensive. Logistic regression was used to investigate associations. Results: After adjusting for demographic, lifestyle and dietary confounders, participants with higher (Q4), compared with lower (Q1) intakes, of total flavonoids, flavan-3-ols, and flavonols had 36% (odds ratio [95% CI], 0.64 [0.43-0.95]), 39% (0.61 [0.40-0.93]) and 38% (0.62 [0.42-0.92]) lower odds of extensive AAC, respectively. In food-based analyses, higher black tea intake, the main source of total flavonoids (75.9%), associated with significantly lower odds of extensive AAC (2-6 cups/d had 16%-42% lower odds compared with 0 daily intake). In a subset of nonconsumers of black tea, the association of total flavonoid intake with AAC remained (Q4 versus Q1 odds ratio [95% CI], 0.11 [0.02-0.54]). Conclusions: In older women, greater habitual dietary flavonoid intake associates with less extensive AAC.
KW - aorta, abdominal
KW - flavonoids
KW - observational study
KW - tea
KW - vascular calcification
KW - vascular diseases
UR - http://www.scopus.com/inward/record.url?scp=85142763254&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.122.318408
DO - 10.1161/ATVBAHA.122.318408
M3 - Article
C2 - 36325901
AN - SCOPUS:85142763254
SN - 1079-5642
VL - 42
SP - 1482
EP - 1494
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 12
ER -