Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men

Lauren C Chasland, Matthew W Knuiman, Mark L Divitini, Kevin Murray, David J Handelsman, Leon Flicker, Graeme J Hankey, Osvaldo P Almeida, Jonathan Golledge, Nicola D Ridgers, Louise H Naylor, Daniel J Green, Bu B Yeap

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Abstract

Objective Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk. Patients 3351 community-dwelling men, mean age 77 years. Measurements Baseline testosterone (T), dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Levels of PA were ascertained by questionnaire. Men were stratified using median splits into high hormone + high PA (H/H), high hormone + low PA (H/L); low hormone + high PA (L/H) and low hormone + low PA (L/L) groups. Results A total of 865 CVD events and 499 CVD deaths occurred during 10-year mean follow-up. Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome. Men with higher T had the lowest risk of incident CVD events, irrespective of PA level. Men with higher T or DHT and higher PA had the lowest risk of dying from CVD (eg, hazard ratios for T/PA H/H 0.76 P = 0.031; H/L 0.85 P = 0.222; L/H 0.80 P = 0.075; L/L 1.00). Conclusion Higher circulating androgens and higher PA were associated with less central adiposity at baseline and fewer CVD deaths during follow-up. These findings are consistent with a potential additive effect of androgens and PA on cardiometabolic outcomes in older men.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalClinical Endocrinology
Volume90
Issue number2
Early online date21 Dec 2018
DOIs
Publication statusPublished - Feb 2019

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Adiposity
Androgens
Exercise
Hormones
Dihydrotestosterone
Gonadal Steroid Hormones
Independent Living
Waist Circumference
Testosterone
Estradiol

Cite this

@article{6559ce1ecda04b3f86e79fe37b776c7d,
title = "Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men",
abstract = "Objective Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk. Patients 3351 community-dwelling men, mean age 77 years. Measurements Baseline testosterone (T), dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Levels of PA were ascertained by questionnaire. Men were stratified using median splits into high hormone + high PA (H/H), high hormone + low PA (H/L); low hormone + high PA (L/H) and low hormone + low PA (L/L) groups. Results A total of 865 CVD events and 499 CVD deaths occurred during 10-year mean follow-up. Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome. Men with higher T had the lowest risk of incident CVD events, irrespective of PA level. Men with higher T or DHT and higher PA had the lowest risk of dying from CVD (eg, hazard ratios for T/PA H/H 0.76 P = 0.031; H/L 0.85 P = 0.222; L/H 0.80 P = 0.075; L/L 1.00). Conclusion Higher circulating androgens and higher PA were associated with less central adiposity at baseline and fewer CVD deaths during follow-up. These findings are consistent with a potential additive effect of androgens and PA on cardiometabolic outcomes in older men.",
keywords = "cardiovascular disease, dihydrotestosterone, metabolic syndrome, physical activity, testosterone, TANDEM MASS-SPECTROMETRY, MYOCARDIAL-INFARCTION, PLASMA TESTOSTERONE, SERUM TESTOSTERONE, REDUCED INCIDENCE, BODY-COMPOSITION, ESTRADIOL LEVELS, MUSCLE STRENGTH, HEART-DISEASE, ALL-CAUSE",
author = "Chasland, {Lauren C} and Knuiman, {Matthew W} and Divitini, {Mark L} and Kevin Murray and Handelsman, {David J} and Leon Flicker and Hankey, {Graeme J} and Almeida, {Osvaldo P} and Jonathan Golledge and Ridgers, {Nicola D} and Naylor, {Louise H} and Green, {Daniel J} and Yeap, {Bu B}",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "2",
doi = "10.1111/cen.13905",
language = "English",
volume = "90",
pages = "375--383",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "John Wiley & Sons",
number = "2",

}

TY - JOUR

T1 - Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men

AU - Chasland, Lauren C

AU - Knuiman, Matthew W

AU - Divitini, Mark L

AU - Murray, Kevin

AU - Handelsman, David J

AU - Flicker, Leon

AU - Hankey, Graeme J

AU - Almeida, Osvaldo P

AU - Golledge, Jonathan

AU - Ridgers, Nicola D

AU - Naylor, Louise H

AU - Green, Daniel J

AU - Yeap, Bu B

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/2

Y1 - 2019/2

N2 - Objective Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk. Patients 3351 community-dwelling men, mean age 77 years. Measurements Baseline testosterone (T), dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Levels of PA were ascertained by questionnaire. Men were stratified using median splits into high hormone + high PA (H/H), high hormone + low PA (H/L); low hormone + high PA (L/H) and low hormone + low PA (L/L) groups. Results A total of 865 CVD events and 499 CVD deaths occurred during 10-year mean follow-up. Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome. Men with higher T had the lowest risk of incident CVD events, irrespective of PA level. Men with higher T or DHT and higher PA had the lowest risk of dying from CVD (eg, hazard ratios for T/PA H/H 0.76 P = 0.031; H/L 0.85 P = 0.222; L/H 0.80 P = 0.075; L/L 1.00). Conclusion Higher circulating androgens and higher PA were associated with less central adiposity at baseline and fewer CVD deaths during follow-up. These findings are consistent with a potential additive effect of androgens and PA on cardiometabolic outcomes in older men.

AB - Objective Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk. Patients 3351 community-dwelling men, mean age 77 years. Measurements Baseline testosterone (T), dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Levels of PA were ascertained by questionnaire. Men were stratified using median splits into high hormone + high PA (H/H), high hormone + low PA (H/L); low hormone + high PA (L/H) and low hormone + low PA (L/L) groups. Results A total of 865 CVD events and 499 CVD deaths occurred during 10-year mean follow-up. Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome. Men with higher T had the lowest risk of incident CVD events, irrespective of PA level. Men with higher T or DHT and higher PA had the lowest risk of dying from CVD (eg, hazard ratios for T/PA H/H 0.76 P = 0.031; H/L 0.85 P = 0.222; L/H 0.80 P = 0.075; L/L 1.00). Conclusion Higher circulating androgens and higher PA were associated with less central adiposity at baseline and fewer CVD deaths during follow-up. These findings are consistent with a potential additive effect of androgens and PA on cardiometabolic outcomes in older men.

KW - cardiovascular disease

KW - dihydrotestosterone

KW - metabolic syndrome

KW - physical activity

KW - testosterone

KW - TANDEM MASS-SPECTROMETRY

KW - MYOCARDIAL-INFARCTION

KW - PLASMA TESTOSTERONE

KW - SERUM TESTOSTERONE

KW - REDUCED INCIDENCE

KW - BODY-COMPOSITION

KW - ESTRADIOL LEVELS

KW - MUSCLE STRENGTH

KW - HEART-DISEASE

KW - ALL-CAUSE

U2 - 10.1111/cen.13905

DO - 10.1111/cen.13905

M3 - Article

VL - 90

SP - 375

EP - 383

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 2

ER -