High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

Simon Ghaly; Kevin Murray; Angela Baird; Katherine Martin; R. Prosser; Justine Mill; L.A. Simms; Prudence H. Hart; G. Radford-Smith; P.A. Bampton; Ian C. Lawrance

doi:10.1097/MIB.0000000000000894

High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

Simon Ghaly
, Kevin Murray
, Angela Baird
, Katherine Martin
, R. Prosser
, Justine Mill
, L.A. Simms
, Prudence H. Hart
, G. Radford-Smith
, P.A. Bampton
, Ian C. Lawrance

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)
UWA Centre for Child Health Research (affiliated with the The Kids Research Institute Australia)

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Background: Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any associations between VDBP, serum 25(OH)D, and the calculated free 25(OH)D concentrations with the risk of disease flare. Methods: Subjects were identified from prospectively maintained inflammatory bowel disease databases at 3 teaching hospitals in Australia. Patients were in steroid-free clinical remission at the time of blood draw and were followed for at least 12 months. Total and epimer-25(OH)D 3, VDBP concentrations, and genotypes were determined. Results: A total of 309 patients with CD (46% men) met the inclusion criteria. A disease flare occurred in 100 (32.4%). Serum 25(OH)D 3 was deficient (

Original language	English
Pages (from-to)	2456-2464
Number of pages	9
Journal	Inflammatory Bowel Diseases
Volume	22
Issue number	10
DOIs	https://doi.org/10.1097/MIB.0000000000000894
Publication status	Published - 26 Aug 2016

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10.1097/MIB.0000000000000894

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@article{58c5504468074bd1a5d24ef796a6b8e9,

title = "High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease",

abstract = "Copyright {\textcopyright} 2016 Crohn's \& Colitis Foundation of America, Inc.Background: Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any associations between VDBP, serum 25(OH)D, and the calculated free 25(OH)D concentrations with the risk of disease flare. Methods: Subjects were identified from prospectively maintained inflammatory bowel disease databases at 3 teaching hospitals in Australia. Patients were in steroid-free clinical remission at the time of blood draw and were followed for at least 12 months. Total and epimer-25(OH)D 3, VDBP concentrations, and genotypes were determined. Results: A total of 309 patients with CD (46\% men) met the inclusion criteria. A disease flare occurred in 100 (32.4\%). Serum 25(OH)D 3 was deficient (",

author = "Simon Ghaly and Kevin Murray and Angela Baird and Katherine Martin and R. Prosser and Justine Mill and L.A. Simms and Hart, \{Prudence H.\} and G. Radford-Smith and P.A. Bampton and Lawrance, \{Ian C.\}",

year = "2016",

month = aug,

day = "26",

doi = "10.1097/MIB.0000000000000894",

language = "English",

volume = "22",

pages = "2456--2464",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

AU - Ghaly, Simon

AU - Murray, Kevin

AU - Baird, Angela

AU - Martin, Katherine

AU - Prosser, R.

AU - Mill, Justine

AU - Simms, L.A.

AU - Hart, Prudence H.

AU - Radford-Smith, G.

AU - Bampton, P.A.

AU - Lawrance, Ian C.

PY - 2016/8/26

Y1 - 2016/8/26

N2 - Copyright © 2016 Crohn's & Colitis Foundation of America, Inc.Background: Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any associations between VDBP, serum 25(OH)D, and the calculated free 25(OH)D concentrations with the risk of disease flare. Methods: Subjects were identified from prospectively maintained inflammatory bowel disease databases at 3 teaching hospitals in Australia. Patients were in steroid-free clinical remission at the time of blood draw and were followed for at least 12 months. Total and epimer-25(OH)D 3, VDBP concentrations, and genotypes were determined. Results: A total of 309 patients with CD (46% men) met the inclusion criteria. A disease flare occurred in 100 (32.4%). Serum 25(OH)D 3 was deficient (

AB - Copyright © 2016 Crohn's & Colitis Foundation of America, Inc.Background: Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any associations between VDBP, serum 25(OH)D, and the calculated free 25(OH)D concentrations with the risk of disease flare. Methods: Subjects were identified from prospectively maintained inflammatory bowel disease databases at 3 teaching hospitals in Australia. Patients were in steroid-free clinical remission at the time of blood draw and were followed for at least 12 months. Total and epimer-25(OH)D 3, VDBP concentrations, and genotypes were determined. Results: A total of 309 patients with CD (46% men) met the inclusion criteria. A disease flare occurred in 100 (32.4%). Serum 25(OH)D 3 was deficient (

U2 - 10.1097/MIB.0000000000000894

DO - 10.1097/MIB.0000000000000894

M3 - Article

C2 - 27631600

SN - 1078-0998

VL - 22

SP - 2456

EP - 2464

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 10

ER -

High Vitamin D-Binding Protein Concentration, Low Albumin, and Mode of Remission Predict Relapse in Crohn's Disease

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