High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis

Steve Simpson-Yap, Wendy H. Oddy, Bruce Taylor, Robyn M. Lucas, Lucinda J. Black, Anne Louise Ponsonby, Leigh Blizzard, Ingrid van der Mei, Keith Dear, Terry Dwyer, Bruce V. Taylor, Simon Broadley, Trevor Kilpatrick, David Williams, Jeanette Lechner-Scott, Cameron Shaw, Caron Chapman, Alan Coulthard, Michael P. Pender, Patricia Valery

Research output: Contribution to journalArticle


Background: Dietary patterns and their association with subsequent clinical course have not been well studied in early multiple sclerosis (MS). Objectives: To describe dietary patterns in people in 5 years following first clinical demyelination and assess associations with MS conversion and relapse. Methods: This study included baseline food frequency questionnaire dietary intake (entry to the Ausimmune Study) and 5-year follow-up; iterated principal factor analysis was applied. MS conversion and relapse risks were assessed by Cox proportional hazards models, adjusted for age, sex, study site, education, body mass index (BMI), smoking and omega-3 supplement use. Results: In cases with a first clinical diagnosis of central nervous system (CNS) demyelination, we identified three major dietary patterns, ‘Prudent’, ‘High-Vegetable’ and ‘Mixed’, explaining 43%, 37% and 24% of diet variance in dietary intake, respectively. Fruits, vegetables, fish, wholegrains and nuts loaded highly on the Prudent pattern, starchy vegetables and legumes on the High-Vegetable pattern, and meats and alcohol on the Mixed pattern. Diet factor scores were not associated with MS conversion risk. Those with baseline Prudent scores above the median had significantly lower relapse risk (adjusted hazard ratio = 0.54, 95% confidence interval (CI) 0.37, 0.81) with some evidence of a plateau effect. Conclusion: Prudent diet factor score above the median was prospectively associated with lower relapse risk in the 5 years following the first clinical demyelinating event.

Original languageEnglish
JournalMultiple Sclerosis Journal
Publication statusE-pub ahead of print - 23 Jul 2020

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