High prevalence and indexes of anti-John Cunningham virus antibodies in a cohort of Chinese patients with multiple sclerosis

Alexander Lau, Wei Qiu, Allan Kermode, Cheryl Au, Angel Ng, Adrian Wong, Sze-Ho Ma, Lisa Au, Karen Ma, Bonaventure Ip, Vincent Mok

Research output: Contribution to journalArticle

Abstract

We performed a cross-sectional study in 123 Chinese multiple sclerosis patients residing in Hong Kong to evaluate their anti-John Cunningham virus status using STRATIFY JCV DxSelect assays. Anti-John Cunningham virus antibody was present in 98/123 (80%) subjects, among which 75/98 (77%) had an anti-John Cunningham virus index ≥1.5. Anti-John Cunningham virus antibody seropositivity was not correlated with age, disease duration, Expanded Disability Status Scale scores, types of multiple sclerosis (relapsing vs progressive), or disease-modifying treatments used. We found a very high seroprevalence and index of anti-John Cunningham virus antibodies in Chinese multiple sclerosis patients, which may impact the risk assessment and recommendation of disease-modifying treatments in this population.

Original languageEnglish
JournalMultiple Sclerosis Journal - Experimental, Translational and Clinical
Volume4
Issue number3
DOIs
Publication statusPublished - 25 Jul 2018

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