High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

Daniel E. Morrison; Jade B. Aitken; Martin D. De Jonge; Joseph A. Ioppolo; Hugh H. Harris; Louis M. Rendina

doi:10.1039/c3cc46903d

High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

Daniel E. Morrison, Jade B. Aitken, Martin D. De Jonge, Joseph A. Ioppolo, Hugh H. Harris, Louis M. Rendina

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The first bifunctional Gd^III complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10¹⁰ Gd atoms per tumour cell.

Original language	English
Pages (from-to)	2252-2254
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	18
DOIs	https://doi.org/10.1039/c3cc46903d
Publication status	Published - 4 Feb 2014
Externally published	Yes

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10.1039/c3cc46903d

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abstract = "The first bifunctional GdIII complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 1010 Gd atoms per tumour cell.",

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AU - Aitken, Jade B.

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AU - Harris, Hugh H.

AU - Rendina, Louis M.

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AB - The first bifunctional GdIII complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 1010 Gd atoms per tumour cell.

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High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

Abstract

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