High and low body temperature during the initiation of ventilation for near-term lambs

M.K. Ball, Alan Jobe, Graeme Polglase, S.G. Kallapur, [No Value] Cheah F-C, N.H. Hillman, Jane Pillow

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    Abstract

    Aims: Recent literature suggests hypothermia may protect against lung injury.We evaluated body temperatureas a variable in lung inflammation due to oxygenation and mechanical ventilation following deliveryof near-term lambs.Methods: Twin fetuseswere randomized prior to delivery at 140 d GA (term 150 d): unventilated controls,normothermic ventilated with room air, normothermic ventilated with 100% oxygen, low temperatureventilated (target 35 ◦C) with 100% oxygen, and high temperature (target 40 ◦C) with 100% oxygen. Lambswere intubated for gentle mechanical ventilation (tidal volume 7–8 ml/kg). Temperature targeting waswith radiant warmers and plastic wrap for normothermia, with heat lamps for hyperthermia, and withice packs for hypothermia. Lambs were euthanized after 2 h mechanical ventilation. Post-mortem, bronchoalveolarlavage fluid and lung tissue sampleswere evaluated for inflammatory responses by measuringinflammatory cell counts, protein, myeloperoxidase, protein carbonyl, and pro-inflammatory cytokinemRNA.Results: Target temperatureswere achieved by 30 min of age and tightly maintained for the 2 h study. Therewere no differences in physiologic variables among groups except those directly resulting from studyprotocol—PaO2 from air vs. 100% oxygen and body temperature. Indicators of inflammation increasedsimilarly in all ventilated groups compared to unventilated controls.Conclusion: Moderate hyperthermia or hypothermia did not affect lung injury responses to the initiationof ventilation at birth in near-term lambs.© 2008 Elsevier Ireland Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)133-137
    JournalResuscitation
    Volume80
    Issue number1
    DOIs
    Publication statusPublished - 2009

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