Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States

Ilkka Heinonen, S. Koga, K.K. Kalliokoski, T.I. Musch, D.C. Poole

    Research output: Contribution to journalArticlepeer-review

    70 Citations (Web of Science)

    Abstract

    © 2015 by the American College of Sports Medicine. The systematic increase in VO2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (QO2)-to-VO2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased QO2/VO2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance.
    Original languageEnglish
    Pages (from-to)117-124
    JournalExercise and Sport Sciences Reviews
    Volume43
    Issue number3
    DOIs
    Publication statusPublished - 2015

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