Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States

Ilkka Heinonen; S. Koga; K.K. Kalliokoski; T.I. Musch; D.C. Poole

doi:10.1249/JES.0000000000000044

Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States

Ilkka Heinonen, S. Koga, K.K. Kalliokoski, T.I. Musch, D.C. Poole

Research output: Contribution to journal › Article › peer-review

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Abstract

© 2015 by the American College of Sports Medicine. The systematic increase in VO2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (QO2)-to-VO2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased QO2/VO2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance.

Original language	English
Pages (from-to)	117-124
Journal	Exercise and Sport Sciences Reviews
Volume	43
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000044
Publication status	Published - 2015

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AU - Poole, D.C.

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AB - © 2015 by the American College of Sports Medicine. The systematic increase in VO2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (QO2)-to-VO2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased QO2/VO2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance.

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Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States

Abstract

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