Hepatosplenic T cell lymphoma presenting as multiorgan failure

Puraskar Pateria, Annalise Martin, Tze Sheng Khor, Vanoo Jayasekeran

Research output: Contribution to journalArticlepeer-review


A 59-year-oldwoman presented with a 2-month history of malaise, abdominal distention and unintentional weight loss. She was initially managed as community acquired pneumonia with a suspicion of underlying chronic liver disease but she deteriorated rapidly into a multiorgan failure necessitating transfer to intensive care unit of a tertiary hospital. She was investigated with liver and bone marrow biopsy that confirmed the diagnosis of hepatosplenic T cell lymphoma. She was treated with cyclophosphamide, doxorubicin, vincristine, etoposide and prednisolone chemotherapy that was changed to salvage ifosfamide carboplatin etoposide (ICE) chemotherapy due to poor response with first-line chemotherapy and disease progression. Unfortunately, her disease progressed further and she opted for palliative management.

Original languageEnglish
Article numbere228186
JournalBMJ Case Reports
Issue number3
Publication statusPublished - 1 Mar 2019
Externally publishedYes


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