Hepatic iron concentration in hereditary hemocrhomatosis does not saturate or accurately predict phlebotomy

John Olynyk, B.A. Luxton, R.S. Britton, B.R. Bacon

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Objective: Biochemical measurement of the hepatic iron concentration (HIC) is essential for the diagnosis of hereditary hemochromatosis (HH). The aim of this study was to determine whether the HIC at the time of diagnosis could predict the subsequent phlebotomy requirements and to determine whether saturation of HIC occurred in HH. Methods: Fifty-four patients (32 male, 22 female) with homozygous HH were evaluated, and HIC was measured in liver biopsies. Patients were subjected to weekly phlebotomy (500 mi) until the transferrin saturation was
    Original languageEnglish
    Pages (from-to)346-350
    JournalThe American Journal of Gastroenterology
    Volume93
    DOIs
    Publication statusPublished - 1998

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