Hepatic iron concentration in hereditary hemocrhomatosis does not saturate or accurately predict phlebotomy

John Olynyk; B.A. Luxton; R.S. Britton; B.R. Bacon

doi:10.1016/S0002-9270(97)00103-2

Hepatic iron concentration in hereditary hemocrhomatosis does not saturate or accurately predict phlebotomy

John Olynyk, B.A. Luxton, R.S. Britton, B.R. Bacon

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21 Citations (Scopus)

Abstract

Objective: Biochemical measurement of the hepatic iron concentration (HIC) is essential for the diagnosis of hereditary hemochromatosis (HH). The aim of this study was to determine whether the HIC at the time of diagnosis could predict the subsequent phlebotomy requirements and to determine whether saturation of HIC occurred in HH. Methods: Fifty-four patients (32 male, 22 female) with homozygous HH were evaluated, and HIC was measured in liver biopsies. Patients were subjected to weekly phlebotomy (500 mi) until the transferrin saturation was

Original language	English
Pages (from-to)	346-350
Journal	The American Journal of Gastroenterology
Volume	93
DOIs	https://doi.org/10.1016/S0002-9270(97)00103-2
Publication status	Published - 1998

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title = "Hepatic iron concentration in hereditary hemocrhomatosis does not saturate or accurately predict phlebotomy",

abstract = "Objective: Biochemical measurement of the hepatic iron concentration (HIC) is essential for the diagnosis of hereditary hemochromatosis (HH). The aim of this study was to determine whether the HIC at the time of diagnosis could predict the subsequent phlebotomy requirements and to determine whether saturation of HIC occurred in HH. Methods: Fifty-four patients (32 male, 22 female) with homozygous HH were evaluated, and HIC was measured in liver biopsies. Patients were subjected to weekly phlebotomy (500 mi) until the transferrin saturation was",

author = "John Olynyk and B.A. Luxton and R.S. Britton and B.R. Bacon",

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T1 - Hepatic iron concentration in hereditary hemocrhomatosis does not saturate or accurately predict phlebotomy

AU - Olynyk, John

AU - Luxton, B.A.

AU - Britton, R.S.

AU - Bacon, B.R.

PY - 1998

Y1 - 1998

N2 - Objective: Biochemical measurement of the hepatic iron concentration (HIC) is essential for the diagnosis of hereditary hemochromatosis (HH). The aim of this study was to determine whether the HIC at the time of diagnosis could predict the subsequent phlebotomy requirements and to determine whether saturation of HIC occurred in HH. Methods: Fifty-four patients (32 male, 22 female) with homozygous HH were evaluated, and HIC was measured in liver biopsies. Patients were subjected to weekly phlebotomy (500 mi) until the transferrin saturation was

AB - Objective: Biochemical measurement of the hepatic iron concentration (HIC) is essential for the diagnosis of hereditary hemochromatosis (HH). The aim of this study was to determine whether the HIC at the time of diagnosis could predict the subsequent phlebotomy requirements and to determine whether saturation of HIC occurred in HH. Methods: Fifty-four patients (32 male, 22 female) with homozygous HH were evaluated, and HIC was measured in liver biopsies. Patients were subjected to weekly phlebotomy (500 mi) until the transferrin saturation was

U2 - 10.1016/S0002-9270(97)00103-2

DO - 10.1016/S0002-9270(97)00103-2

M3 - Article

SN - 0002-9270

VL - 93

SP - 346

EP - 350

JO - The American Journal of Gastroenterology

JF - The American Journal of Gastroenterology

ER -

Hepatic iron concentration in hereditary hemocrhomatosis does not saturate or accurately predict phlebotomy

Abstract

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