Hemodynamic Implications of STABILISE Technique for Aortic Dissection Repair

Jens C. Ritter, Bijit Munshi, Nathan Letizia, Louis P. Parker, Lachlan J. Kelsey, Molly Gilfillan, Uyen G. Vo, Barry J. Doyle

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The stent-assisted balloon-induced intimal disruption and relamination (STABILISE) technique for treatment of type B dissection has shown promising clinical results at mid-term. Computational modeling is a way of noninvasively obtaining hemodynamic effects, such as pressure and wall shear stress, leading to a better understanding of potential benefits. Particular areas of interest are (1) the effect of intimal disruption and re-lamination and (2) the effect of the bare metal stent in the visceral aortic segment. Methods: Single-center prospective case series. Data from 5 consecutive locally performed cases of STABILISE technique were analyzed. Included cases were type B aortic dissection with or without prior de-branching. The STABILISE procedure had to be performed without 30-day major complications. Preoperative and postoperative imaging data for each patient were transferred to the biomedical engineering team. Each case was reconstructed, meshed, and simulated with computational fluid dynamics using patient-specific data (heart rate, blood pressure, height, and weight). Hemodynamic parameters were then extracted from the simulations. Results: In all cases, computational analysis showed for postoperative patients: (1) a drop in pressure difference between lumina and (2) lower wall shear stress effects, compared to their preoperative status. These observations were most pronounced in the visceral aortic segment. Conclusions: Computational modeling shows favourable changes in the flow dynamics of type B dissection treated using the STABILISE technique. This may suggest protective effects of this technique for long-term aortic healing and cicatrization.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalAnnals of vascular surgery
Volume98
Early online date5 Oct 2023
DOIs
Publication statusPublished - Jan 2024

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