Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females

Marzena Pedrini, Alexandra Seewann-Gaitatzis, K.A. Bennett, Alex Wood, I. James, J. Burton, Barry Marshall, Bill Carroll, Allan Kermode

Research output: Contribution to journalLetter

29 Citations (Scopus)

Abstract

Background: In recent years, a relationship between Helicobacter pylori and many disease conditions has been reported, however, studies in its relationship with multiple sclerosis (MS) have had contradictory results.

Objective: To determine the association between the H. pylori infection and MS.

Methods: 550 patients with MS were included in the study and were matched by gender and year of birth to 299 controls. Patients were assessed for clinical and demographic parameters. An enzyme immunoassay was used to detect the presence of specific IgG antibodies against H. pylori in the serum sample of both groups.

Results: H. pylori seropositivity was found to be lower in the patients with MS than in controls (16% vs 21%) with the decrease pertaining to females (14% vs 22%, p=0.027) but not males (19% vs 20%, p=1.0). When adjusted for age at onset, year of birth and disease duration, H. pylori seropositive females presented with a lower disability score than seronegative females (p=0.049), while among males the reverse was true (p=0.025). There was no significant association between H. pylori seropositivity and relapse rate.

Conclusions: Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the 'hygiene hypothesis', a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.
Original languageEnglish
Pages (from-to)603-607
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume86
Issue number6
Early online date19 Jan 2015
DOIs
Publication statusPublished - Jun 2015

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Helicobacter Infections
Helicobacter pylori
Multiple Sclerosis
Hygiene Hypothesis
Parturition
Protective Factors
Immunoenzyme Techniques
Age of Onset
Immune System
Immunoglobulin G
Biomarkers
Demography
Recurrence
Antibodies
Infection
Serum

Cite this

Pedrini, Marzena ; Seewann-Gaitatzis, Alexandra ; Bennett, K.A. ; Wood, Alex ; James, I. ; Burton, J. ; Marshall, Barry ; Carroll, Bill ; Kermode, Allan. / Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females. In: Journal of Neurology, Neurosurgery and Psychiatry. 2015 ; Vol. 86, No. 6. pp. 603-607.
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title = "Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females",
abstract = "Background: In recent years, a relationship between Helicobacter pylori and many disease conditions has been reported, however, studies in its relationship with multiple sclerosis (MS) have had contradictory results. Objective: To determine the association between the H. pylori infection and MS. Methods: 550 patients with MS were included in the study and were matched by gender and year of birth to 299 controls. Patients were assessed for clinical and demographic parameters. An enzyme immunoassay was used to detect the presence of specific IgG antibodies against H. pylori in the serum sample of both groups. Results: H. pylori seropositivity was found to be lower in the patients with MS than in controls (16{\%} vs 21{\%}) with the decrease pertaining to females (14{\%} vs 22{\%}, p=0.027) but not males (19{\%} vs 20{\%}, p=1.0). When adjusted for age at onset, year of birth and disease duration, H. pylori seropositive females presented with a lower disability score than seronegative females (p=0.049), while among males the reverse was true (p=0.025). There was no significant association between H. pylori seropositivity and relapse rate. Conclusions: Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the 'hygiene hypothesis', a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.",
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Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females. / Pedrini, Marzena; Seewann-Gaitatzis, Alexandra; Bennett, K.A.; Wood, Alex; James, I.; Burton, J.; Marshall, Barry; Carroll, Bill; Kermode, Allan.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 86, No. 6, 06.2015, p. 603-607.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females

AU - Pedrini, Marzena

AU - Seewann-Gaitatzis, Alexandra

AU - Bennett, K.A.

AU - Wood, Alex

AU - James, I.

AU - Burton, J.

AU - Marshall, Barry

AU - Carroll, Bill

AU - Kermode, Allan

PY - 2015/6

Y1 - 2015/6

N2 - Background: In recent years, a relationship between Helicobacter pylori and many disease conditions has been reported, however, studies in its relationship with multiple sclerosis (MS) have had contradictory results. Objective: To determine the association between the H. pylori infection and MS. Methods: 550 patients with MS were included in the study and were matched by gender and year of birth to 299 controls. Patients were assessed for clinical and demographic parameters. An enzyme immunoassay was used to detect the presence of specific IgG antibodies against H. pylori in the serum sample of both groups. Results: H. pylori seropositivity was found to be lower in the patients with MS than in controls (16% vs 21%) with the decrease pertaining to females (14% vs 22%, p=0.027) but not males (19% vs 20%, p=1.0). When adjusted for age at onset, year of birth and disease duration, H. pylori seropositive females presented with a lower disability score than seronegative females (p=0.049), while among males the reverse was true (p=0.025). There was no significant association between H. pylori seropositivity and relapse rate. Conclusions: Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the 'hygiene hypothesis', a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.

AB - Background: In recent years, a relationship between Helicobacter pylori and many disease conditions has been reported, however, studies in its relationship with multiple sclerosis (MS) have had contradictory results. Objective: To determine the association between the H. pylori infection and MS. Methods: 550 patients with MS were included in the study and were matched by gender and year of birth to 299 controls. Patients were assessed for clinical and demographic parameters. An enzyme immunoassay was used to detect the presence of specific IgG antibodies against H. pylori in the serum sample of both groups. Results: H. pylori seropositivity was found to be lower in the patients with MS than in controls (16% vs 21%) with the decrease pertaining to females (14% vs 22%, p=0.027) but not males (19% vs 20%, p=1.0). When adjusted for age at onset, year of birth and disease duration, H. pylori seropositive females presented with a lower disability score than seronegative females (p=0.049), while among males the reverse was true (p=0.025). There was no significant association between H. pylori seropositivity and relapse rate. Conclusions: Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the 'hygiene hypothesis', a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.

U2 - 10.1136/jnnp-2014-309495

DO - 10.1136/jnnp-2014-309495

M3 - Letter

VL - 86

SP - 603

EP - 607

JO - Journal of Neurology and Neurosurgical Psychiatry

JF - Journal of Neurology and Neurosurgical Psychiatry

SN - 0022-3050

IS - 6

ER -