Helicobacter pylori genomic microevolution during naturally occurring transmission between adults

B. Linz, Helen Windsor, J.P. Gajewski, C.M. Hake, D.I. Drautz, S.C. Schuster, Barry Marshall

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    The human gastric pathogen Helicobacter pylori is usually acquired during childhood and, in the absence of treatment, chronic infection persists through most of the host's life. However, the frequency and importance of H. pylori transmission between adults is underestimated. Here we sequenced the complete genomes of H. pylori strains that were transmitted between spouses and analysed the genomic changes. Similar to H. pylori from chronic infection, a significantly high proportion of the determined 31 SNPs and 10 recombinant DNA fragments affected genes of the hop family of outer membrane proteins, some of which are known to be adhesins. In addition, changes in a fucosyltransferase gene modified the LPS component of the bacterial cell surface, suggesting strong diversifying selection. In contrast, virulence factor genes were not affected by the genomic changes. We propose a model of the genomic changes that are associated with the transmission and adaptation of H. pylori to a new human host. © 2013 Linz et al.
    Original languageEnglish
    Pages (from-to)Article number e82187
    JournalPLoS One
    Volume8
    Issue number12
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Helicobacter pylori
    Genes
    genomics
    Fucosyltransferases
    Recombinant DNA
    Virulence Factors
    Pathogens
    spouses
    Humulus
    adhesins
    recombinant DNA
    genes
    outer membrane proteins
    hops
    Cellular Structures
    Membrane Proteins
    Infection
    Spouses
    childhood
    infection

    Cite this

    Linz, B., Windsor, H., Gajewski, J. P., Hake, C. M., Drautz, D. I., Schuster, S. C., & Marshall, B. (2013). Helicobacter pylori genomic microevolution during naturally occurring transmission between adults. PLoS One, 8(12), Article number e82187. https://doi.org/10.1371/journal.pone.0082187
    Linz, B. ; Windsor, Helen ; Gajewski, J.P. ; Hake, C.M. ; Drautz, D.I. ; Schuster, S.C. ; Marshall, Barry. / Helicobacter pylori genomic microevolution during naturally occurring transmission between adults. In: PLoS One. 2013 ; Vol. 8, No. 12. pp. Article number e82187.
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    Linz, B, Windsor, H, Gajewski, JP, Hake, CM, Drautz, DI, Schuster, SC & Marshall, B 2013, 'Helicobacter pylori genomic microevolution during naturally occurring transmission between adults' PLoS One, vol. 8, no. 12, pp. Article number e82187. https://doi.org/10.1371/journal.pone.0082187

    Helicobacter pylori genomic microevolution during naturally occurring transmission between adults. / Linz, B.; Windsor, Helen; Gajewski, J.P.; Hake, C.M.; Drautz, D.I.; Schuster, S.C.; Marshall, Barry.

    In: PLoS One, Vol. 8, No. 12, 2013, p. Article number e82187.

    Research output: Contribution to journalArticle

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    Linz B, Windsor H, Gajewski JP, Hake CM, Drautz DI, Schuster SC et al. Helicobacter pylori genomic microevolution during naturally occurring transmission between adults. PLoS One. 2013;8(12):Article number e82187. https://doi.org/10.1371/journal.pone.0082187