Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism with Relevance to Nutrition and Appetite Regulation in Diabetes

Dyslipidemia is one of the key risk factors for cardiovascular disease with relevance to non alcoholic fatty liver disease (NAFLD) and diabetes. The management of dyslipidemia in diabetes continues to remain controversial and improvements in the characteristic diabetic dyslipidemia of high triglyceride and low HDL may now indicate that defective mitochondrial biogenesis is underway early in life. Diabetes and defective mitochondrial function induce delayed postprandial lipid metabolism that is involved in diabetic dyslipidemia. The clinical management of diabetes in the young and elderly now involves the heat shock gene Sirtuin 1 (Sirt 1) involved with careful core body temperature regulation and maintenance of liver and brain mitochondrial energy metabolism. Consumption of Sirt 1 inhibitors such as alcohol, suramin and palmitic acid should be avoided to prevent cell mitochondrial apoptosis and to stabilize NAFLD with relevance to hyperglycemia induced oxidative stress and myocardial infarction.