Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry

Ian N. Glaspole, Sally A. Chapman, Wendy A. Cooper, Samantha J. Ellis, Nicole S. Goh, Peter M. Hopkins, Sacha Macansh, Annabelle Mahar, Yuben P. Moodley, Eldho Paul, Paul N. Reynolds, E. Haydn Walters, Christopher J. Zappala, Tamera J. Corte

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background and objective: Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis (IPF) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health-related quality of life (HRQoL) in a large unselected IPF population. Methods: We used the Australian IPF Registry to examine the relationship between HRQoL, measured using the St George Respiratory Questionnaire (SGRQ), and demographic features, physiological features, co-morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL, linear mixed model analysis to determine the effect of time and forced vital capacity (FVC) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all-cause mortality. Results: Baseline data from 516 patients were available (347 males; mean (SD) age: 71.3±8.6years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire (UCSD-SOBQ); R2 = 0.71, P2 = 0.06, P2 = 0.04, P

Original languageEnglish
Pages (from-to)950-956
JournalRespirology
Volume22
Issue number5
DOIs
Publication statusPublished - Jul 2017

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Idiopathic Pulmonary Fibrosis
Registries
Quality of Life
Dyspnea
Linear Models
Demography
Vital Capacity
Population
Multivariate Analysis
Regression Analysis
Morbidity
Lung
Mortality
Surveys and Questionnaires

Cite this

Glaspole, I. N., Chapman, S. A., Cooper, W. A., Ellis, S. J., Goh, N. S., Hopkins, P. M., ... Corte, T. J. (2017). Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry. Respirology, 22(5), 950-956. https://doi.org/10.1111/resp.12989
Glaspole, Ian N. ; Chapman, Sally A. ; Cooper, Wendy A. ; Ellis, Samantha J. ; Goh, Nicole S. ; Hopkins, Peter M. ; Macansh, Sacha ; Mahar, Annabelle ; Moodley, Yuben P. ; Paul, Eldho ; Reynolds, Paul N. ; Walters, E. Haydn ; Zappala, Christopher J. ; Corte, Tamera J. / Health-related quality of life in idiopathic pulmonary fibrosis : Data from the Australian IPF Registry. In: Respirology. 2017 ; Vol. 22, No. 5. pp. 950-956.
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Glaspole, IN, Chapman, SA, Cooper, WA, Ellis, SJ, Goh, NS, Hopkins, PM, Macansh, S, Mahar, A, Moodley, YP, Paul, E, Reynolds, PN, Walters, EH, Zappala, CJ & Corte, TJ 2017, 'Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry' Respirology, vol. 22, no. 5, pp. 950-956. https://doi.org/10.1111/resp.12989

Health-related quality of life in idiopathic pulmonary fibrosis : Data from the Australian IPF Registry. / Glaspole, Ian N.; Chapman, Sally A.; Cooper, Wendy A.; Ellis, Samantha J.; Goh, Nicole S.; Hopkins, Peter M.; Macansh, Sacha; Mahar, Annabelle; Moodley, Yuben P.; Paul, Eldho; Reynolds, Paul N.; Walters, E. Haydn; Zappala, Christopher J.; Corte, Tamera J.

In: Respirology, Vol. 22, No. 5, 07.2017, p. 950-956.

Research output: Contribution to journalArticle

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T1 - Health-related quality of life in idiopathic pulmonary fibrosis

T2 - Data from the Australian IPF Registry

AU - Glaspole, Ian N.

AU - Chapman, Sally A.

AU - Cooper, Wendy A.

AU - Ellis, Samantha J.

AU - Goh, Nicole S.

AU - Hopkins, Peter M.

AU - Macansh, Sacha

AU - Mahar, Annabelle

AU - Moodley, Yuben P.

AU - Paul, Eldho

AU - Reynolds, Paul N.

AU - Walters, E. Haydn

AU - Zappala, Christopher J.

AU - Corte, Tamera J.

PY - 2017/7

Y1 - 2017/7

N2 - Background and objective: Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis (IPF) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health-related quality of life (HRQoL) in a large unselected IPF population. Methods: We used the Australian IPF Registry to examine the relationship between HRQoL, measured using the St George Respiratory Questionnaire (SGRQ), and demographic features, physiological features, co-morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL, linear mixed model analysis to determine the effect of time and forced vital capacity (FVC) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all-cause mortality. Results: Baseline data from 516 patients were available (347 males; mean (SD) age: 71.3±8.6years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire (UCSD-SOBQ); R2 = 0.71, P2 = 0.06, P2 = 0.04, P

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KW - Cough

KW - Dyspnoea

KW - Forced vital capacity

KW - Pulmonary fibrosis

KW - Quality of life

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Glaspole IN, Chapman SA, Cooper WA, Ellis SJ, Goh NS, Hopkins PM et al. Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry. Respirology. 2017 Jul;22(5):950-956. https://doi.org/10.1111/resp.12989