Level of satisfaction is significantly influenced by health-related factors across human life course. Prior research shows that there are variations in the relationship between health factors and life-satisfaction between Western and Asian countries. This study aimed to explore health determinants of life satisfaction among older adults in Brunei Darussalam. Cross-sectional study using an interviewer-assisted questionnaire. Six hundred forty-five adults aged above 50 years were recruited nationally. Descriptive statistics and multivariate regression analysis were applied. A robust model (R2 = 49.3%, alpha > 0.7) suggested that life satisfaction in this population could largely be explained by musculoskeletal pain, difficulty to perform daily activities, psychological and emotional issues, and family support. Gender has significant moderating effects on this relationship. Impacts of life satisfaction from health, social, cultural, and related perspectives were discussed. These findings in this research may contribute to ongoing multi-sectorial efforts to design a comprehensive model of care of older people to achieve high quality of life.