Research output per year
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Abstract
Immune checkpoint blockade (ICB) alone or in combination with chemotherapy are promising therapies that produce durable responses in a minority of patients with mesothelioma. To understand why this is so, this thesis characterised T cells in murine models of mesothelioma, particularly in the context of durable responses to effective chemotherapy and ICB combinations. It identified T cell markers that can be used to predict and improve therapy outcomes. Characterisation of T cells from malignant pleural effusions (MPE) of mesothelioma patients revealed the expression of these markers, suggesting that MPE T cells as a valuable tool to track therapy responses.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 4 Jun 2024 |
| DOIs | |
| Publication status | Published - 2023 |
Embargo information
- Embargoed from 03/06/2024 to 01/05/2025. Made publicly available on 01/05/2025.
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Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations
Principe, N., Aston, W. J., Hope, D. E., Tilsed, C. M., Fisher, S. A., Boon, L., Dick, I. M., Chin, W. L., McDonnell, A. M., Nowak, A. K., Lake, R. A., Chee, J. & Lesterhuis, W. J., 11 May 2022, In: Frontiers in Immunology. 13, 872295.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?
Principe, N., Kidman, J., Lake, R. A., Lesterhuis, W. J., Nowak, A. K., McDonnell, A. M. & Chee, J., 27 Apr 2021, In: Frontiers in Oncology. 11, 672747.Research output: Contribution to journal › Review article › peer-review
Open Access16 Citations (Scopus) -
Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy
Principe, N., Kidman, J., Goh, S., Tilsed, C. M., Fisher, S. A., Fear, V. S., Forbes, C. A., Zemek, R. M., Chopra, A., Watson, M., Dick, I. M., Boon, L., Holt, R. A., Lake, R. A., Nowak, A. K., Lesterhuis, W. J., McDonnell, A. M. & Chee, J., 12 Nov 2020, In: Frontiers in Immunology. 11, 584423.Research output: Contribution to journal › Article › peer-review
Open Access50 Citations (Scopus)