Abstract

Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user’s hand. In this paper, we present a proof-of-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps, minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability to distinguish stiff cancerous tissue from surrounding soft benign tissue.

Original languageEnglish
Pages (from-to)4034-4049
Number of pages16
JournalBiomedical Optics Express
Volume10
Issue number8
DOIs
Publication statusPublished - 1 Aug 2019

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Elasticity Imaging Techniques
probes
artifacts
acquisition
Artifacts
histology
silicones
breast
scanners
seats
microelectromechanical systems
Silicones
actuators
Histology
Breast
Hand
scanning
Equipment and Supplies

Cite this

@article{7fdc58116f4947fa8a042dacb9388b33,
title = "Handheld probe for quantitative micro-elastography",
abstract = "Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user’s hand. In this paper, we present a proof-of-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps, minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability to distinguish stiff cancerous tissue from surrounding soft benign tissue.",
author = "Fang, {Q. I.} and Brooke Krajancich and Lixin Chin and Renate Zilkens and Andrea Curatolo and Luke Frewer and Anstie, {James D.} and Philip Wijesinghe and Colin Hall and Dessauvagie, {Benjamin F.} and Bruce Latham and Saunders, {Christobel M.} and Kennedy, {Brendan F.}",
year = "2019",
month = "8",
day = "1",
doi = "10.1364/BOE.10.004034",
language = "English",
volume = "10",
pages = "4034--4049",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "Optical Soc Amer",
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}

Handheld probe for quantitative micro-elastography. / Fang, Q. I.; Krajancich, Brooke; Chin, Lixin; Zilkens, Renate; Curatolo, Andrea; Frewer, Luke; Anstie, James D.; Wijesinghe, Philip; Hall, Colin; Dessauvagie, Benjamin F.; Latham, Bruce; Saunders, Christobel M.; Kennedy, Brendan F.

In: Biomedical Optics Express, Vol. 10, No. 8, 01.08.2019, p. 4034-4049.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Handheld probe for quantitative micro-elastography

AU - Fang, Q. I.

AU - Krajancich, Brooke

AU - Chin, Lixin

AU - Zilkens, Renate

AU - Curatolo, Andrea

AU - Frewer, Luke

AU - Anstie, James D.

AU - Wijesinghe, Philip

AU - Hall, Colin

AU - Dessauvagie, Benjamin F.

AU - Latham, Bruce

AU - Saunders, Christobel M.

AU - Kennedy, Brendan F.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user’s hand. In this paper, we present a proof-of-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps, minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability to distinguish stiff cancerous tissue from surrounding soft benign tissue.

AB - Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user’s hand. In this paper, we present a proof-of-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps, minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability to distinguish stiff cancerous tissue from surrounding soft benign tissue.

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DO - 10.1364/BOE.10.004034

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JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

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