Halomethane biosynthesis: Structure of a SAM-dependent halide methyltransferase from arabidopsis thaliana

Jason W. Schmidberger; A.B. B. James; R. Edwards; J.H. H. Naismith; D. O&apos;Hagan

doi:10.1002/anie.201000119

Halomethane biosynthesis: Structure of a SAM-dependent halide methyltransferase from arabidopsis thaliana

Jason W. Schmidberger, A.B. B. James, R. Edwards, J.H. H. Naismith, D. O'Hagan

School of Molecular Sciences

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Abstract

It's a gas ! The structure of the halomethane-producing halo/thiocyanate methyltransferase enzyme from plants has been determined. The halide ion and the methyl group of S-adenosyl-L-methionine (SAM) were modeled into the active site (see picture; chloride: green sphere; SAM: C green, O red, S yellow, N blue), which indicated their predisposition for reaction. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	3646-3648
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	21
DOIs	https://doi.org/10.1002/anie.201000119
Publication status	Published - 2010

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abstract = "It's a gas ! The structure of the halomethane-producing halo/thiocyanate methyltransferase enzyme from plants has been determined. The halide ion and the methyl group of S-adenosyl-L-methionine (SAM) were modeled into the active site (see picture; chloride: green sphere; SAM: C green, O red, S yellow, N blue), which indicated their predisposition for reaction. (Figure Presented) {\textcopyright} 2010 Wiley-VCH Verlag GmbH & Co. KGaA.",

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AU - O'Hagan, D.

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AB - It's a gas ! The structure of the halomethane-producing halo/thiocyanate methyltransferase enzyme from plants has been determined. The halide ion and the methyl group of S-adenosyl-L-methionine (SAM) were modeled into the active site (see picture; chloride: green sphere; SAM: C green, O red, S yellow, N blue), which indicated their predisposition for reaction. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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DO - 10.1002/anie.201000119

M3 - Article

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Halomethane biosynthesis: Structure of a SAM-dependent halide methyltransferase from arabidopsis thaliana

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