TY - JOUR
T1 - Hallucinations Under Psychedelics and in the Schizophrenia Spectrum
T2 - An Interdisciplinary and Multiscale Comparison
AU - Leptourgos, Pantelis
AU - Fortier-Davy, Martin
AU - Carhart-Harris, Robin
AU - Corlett, Philip R.
AU - Dupuis, David
AU - Halberstadt, Adam L.
AU - Kometer, Michael
AU - Kozakova, Eva
AU - LarØi, Frank
AU - Noorani, Tehseen N.
AU - Preller, Katrin H.
AU - Waters, Flavie
AU - Zaytseva, Yuliya
AU - Jardri, Renaud
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.
AB - The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.
KW - Bayesian
KW - computational
KW - hallucinations
KW - psychedelics
KW - psychosis
KW - serotonin
UR - http://www.scopus.com/inward/record.url?scp=85097113288&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbaa117
DO - 10.1093/schbul/sbaa117
M3 - Article
C2 - 32944778
AN - SCOPUS:85097113288
VL - 46
SP - 1396
EP - 1408
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 6
ER -
