Haemochromatosis

Paul C. Adams, Gary Jeffrey, John Ryan

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Haemochromatosis is one of the most common genetic diseases affecting patients of northern European ancestry. It is overdiagnosed in patients without iron overload and is underdiagnosed in many patients. Early diagnosis by genetic testing and therapy by periodic phlebotomy can prevent the most serious complications, which include liver cirrhosis, liver cancer, and death. This Seminar includes an update on the origins of haemochromatosis; and an overview pathophysiology, genetics, natural history, signs and symptoms, differential diagnoses, treatment with phlebotomy, outcomes, and future directions.

Original languageEnglish
Pages (from-to)1811-1821
Number of pages11
JournalThe Lancet
Volume401
Issue number10390
DOIs
Publication statusPublished - 27 May 2023

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