Habitual prospective memory in HIV disease

K.L. Doyle, E. Weber, E.E. Morgan, Shayne Loft, C. Cushman, J. Villalobos, E. Johnston, Steven Woods

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: HIV-associated neurocognitive disorders (HAND) are associated with deficits in prospective memory (PM). However, most PM research in HIV has used single-event tasks as opposed to habitual PM paradigms, which may be more relevant to clinical populations for whom many health-care behaviors must be performed both frequently and routinely. Method: For the current study, we examined habitual PM and its associations with real-world functioning outcomes in 36 HIV+ individuals with HAND (HAND+), 70 HIV+ individuals without HAND (HAND-), and 115 HIV- individuals. The ongoing task consisted of 24 1-min Stroop trial blocks in which the emotive and cognitive load was manipulated. The habitual PM task required participants to press the spacebar once per block, but only after 20 s had elapsed. Results: A series of MANOVAs covarying for relevant clinicodemographic factors revealed a main effect of study group on habitual PM, such that the HAND+ cohort made significantly more repetition errors than the HIV- and HAND- groups, particularly during early trial blocks. There was no main effect of ongoing task demands, nor was there an interaction between HAND group and task demands. Within the entire HIV+ sample, poorer habitual PM was associated with deficits in learning and dysfunction in real-world outcomes, including medication nonadherence and failures on a naturalistic health-care task. Conclusion: Findings indicate that HAND may be associated with deficient internal source monitoring or temporal discrimination for habitual PM output that may play a critical role in real-world functioning, including HIV disease management.
Original languageEnglish
Pages (from-to)909-918
JournalNeuropsychology
Volume29
Issue number6
DOIs
Publication statusPublished - 2015

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    Doyle, K. L., Weber, E., Morgan, E. E., Loft, S., Cushman, C., Villalobos, J., ... Woods, S. (2015). Habitual prospective memory in HIV disease. Neuropsychology, 29(6), 909-918. https://doi.org/10.1037/neu0000180