Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

Belinda M. Brown, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Stephanie R. Rainey-Smith, Jeremiah J. Peiffer, Chengjie Xiong, Anne M. Fagan, Tammie Benzinger, Virginia Buckles, Kirk I. Erickson, Roger Clarnette, Tejal Shah, Colin L. Masters, Michael Weiner, Nigel Cairns, Martin Rossor, Neill R. Graff-Radford, Stephen Salloway, Jonathan Vöglein & 6 others Christoph Laske, James Noble, Peter R. Schofield, Randall J. Bateman, John C. Morris, Ralph N. Martins

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42 and CSF tau levels was evaluated using linear regression. Results No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Discussion Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.

Original languageEnglish
Pages (from-to)1197-1206
Number of pages10
JournalAlzheimer's and Dementia
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

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Amyloid
Alzheimer Disease
Cerebrospinal Fluid
Brain
Mutation
Linear Models
Biomarkers
Pathology

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Brown, Belinda M. ; Sohrabi, Hamid R. ; Taddei, Kevin ; Gardener, Samantha L. ; Rainey-Smith, Stephanie R. ; Peiffer, Jeremiah J. ; Xiong, Chengjie ; Fagan, Anne M. ; Benzinger, Tammie ; Buckles, Virginia ; Erickson, Kirk I. ; Clarnette, Roger ; Shah, Tejal ; Masters, Colin L. ; Weiner, Michael ; Cairns, Nigel ; Rossor, Martin ; Graff-Radford, Neill R. ; Salloway, Stephen ; Vöglein, Jonathan ; Laske, Christoph ; Noble, James ; Schofield, Peter R. ; Bateman, Randall J. ; Morris, John C. ; Martins, Ralph N. / Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease. In: Alzheimer's and Dementia. 2017 ; Vol. 13, No. 11. pp. 1197-1206.
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abstract = "Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42 and CSF tau levels was evaluated using linear regression. Results No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Discussion Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.",
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author = "Brown, {Belinda M.} and Sohrabi, {Hamid R.} and Kevin Taddei and Gardener, {Samantha L.} and Rainey-Smith, {Stephanie R.} and Peiffer, {Jeremiah J.} and Chengjie Xiong and Fagan, {Anne M.} and Tammie Benzinger and Virginia Buckles and Erickson, {Kirk I.} and Roger Clarnette and Tejal Shah and Masters, {Colin L.} and Michael Weiner and Nigel Cairns and Martin Rossor and Graff-Radford, {Neill R.} and Stephen Salloway and Jonathan V{\"o}glein and Christoph Laske and James Noble and Schofield, {Peter R.} and Bateman, {Randall J.} and Morris, {John C.} and Martins, {Ralph N.}",
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Brown, BM, Sohrabi, HR, Taddei, K, Gardener, SL, Rainey-Smith, SR, Peiffer, JJ, Xiong, C, Fagan, AM, Benzinger, T, Buckles, V, Erickson, KI, Clarnette, R, Shah, T, Masters, CL, Weiner, M, Cairns, N, Rossor, M, Graff-Radford, NR, Salloway, S, Vöglein, J, Laske, C, Noble, J, Schofield, PR, Bateman, RJ, Morris, JC & Martins, RN 2017, 'Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease' Alzheimer's and Dementia, vol. 13, no. 11, pp. 1197-1206. https://doi.org/10.1016/j.jalz.2017.03.008

Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease. / Brown, Belinda M.; Sohrabi, Hamid R.; Taddei, Kevin; Gardener, Samantha L.; Rainey-Smith, Stephanie R.; Peiffer, Jeremiah J.; Xiong, Chengjie; Fagan, Anne M.; Benzinger, Tammie; Buckles, Virginia; Erickson, Kirk I.; Clarnette, Roger; Shah, Tejal; Masters, Colin L.; Weiner, Michael; Cairns, Nigel; Rossor, Martin; Graff-Radford, Neill R.; Salloway, Stephen; Vöglein, Jonathan; Laske, Christoph; Noble, James; Schofield, Peter R.; Bateman, Randall J.; Morris, John C.; Martins, Ralph N.

In: Alzheimer's and Dementia, Vol. 13, No. 11, 01.11.2017, p. 1197-1206.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

AU - Brown, Belinda M.

AU - Sohrabi, Hamid R.

AU - Taddei, Kevin

AU - Gardener, Samantha L.

AU - Rainey-Smith, Stephanie R.

AU - Peiffer, Jeremiah J.

AU - Xiong, Chengjie

AU - Fagan, Anne M.

AU - Benzinger, Tammie

AU - Buckles, Virginia

AU - Erickson, Kirk I.

AU - Clarnette, Roger

AU - Shah, Tejal

AU - Masters, Colin L.

AU - Weiner, Michael

AU - Cairns, Nigel

AU - Rossor, Martin

AU - Graff-Radford, Neill R.

AU - Salloway, Stephen

AU - Vöglein, Jonathan

AU - Laske, Christoph

AU - Noble, James

AU - Schofield, Peter R.

AU - Bateman, Randall J.

AU - Morris, John C.

AU - Martins, Ralph N.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42 and CSF tau levels was evaluated using linear regression. Results No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Discussion Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.

AB - Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42 and CSF tau levels was evaluated using linear regression. Results No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels. Discussion Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers.

KW - Alzheimer's disease

KW - Amyloid β

KW - Dementia

KW - Genetics

KW - Physical activity

KW - Tau

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U2 - 10.1016/j.jalz.2017.03.008

DO - 10.1016/j.jalz.2017.03.008

M3 - Article

VL - 13

SP - 1197

EP - 1206

JO - ALZHEIMERS & DEMENTIA

JF - ALZHEIMERS & DEMENTIA

SN - 1552-5260

IS - 11

ER -