H-bond network, interfacial tension and chain melting temperature govern phospholipid self-assembly in ionic liquids

Livia Salvati Manni, Wye-Khay Fong, Kathleen Wood, Nigel Kirby, Susanne Seibt, Rob Atkin, Gregory G. Warr

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Hypothesis: The self-assembly structures and phase behaviour of phospholipids in protic ionic liquids (ILs) depend on intermolecular forces that can be controlled through changes in the size, polarity, and H-bond capacity of the solvent.Experiments: The structure and temperature stability of the self-assembled phases formed by four phospholipids in three ILs was determined by a combination of small-and wide-angle X-ray scattering (SAXS and WAXS) and small-angle neutron scattering (SANS). The phospholipids have identical phosphocholine head groups but different alkyl tail lengths and saturations (DOPC, POPC, DPPC and DSPC), while the ILs' amphiphilicity, H-bond network density and polarity are varied between propylammonium nitrate (PAN) to ethylammonium nitrate (EAN) to ethanolammonium nitrate (EtAN).Findings: The observed structures and phase behaviour of the lipids becomes more surfactant-like with decreasing average solvent polarity, H-bond network density and surface tension. In PAN, all the investigated phospholipids behave like surfactants in water. In EAN they exhibit anomalous phase sequences and unexpected transitions as a function of temperature, while EtAN supports structures that share characteristics with water and EAN. Structures formed are also sensitive to proximity to the lipid chain melting temperature.
Original languageEnglish
Pages (from-to)320-326
Number of pages7
JournalJournal of Colloid and Interface Science
Volume657
Early online date4 Dec 2023
DOIs
Publication statusPublished - Mar 2024

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