TY - JOUR
T1 - GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
AU - Early Growth Genetics (EGG) Consortium
AU - BIOS consortium
AU - Alves, Alexessander Couto
AU - De Silva, N. Maneka G.
AU - Karhunen, Ville
AU - Sovio, Ulla
AU - Das, Shikta
AU - Rob Taal, H.
AU - Warrington, Nicole M.
AU - Lewin, Alexandra M.
AU - Kaakinen, Marika
AU - Cousminer, Diana L.
AU - Thiering, Elisabeth
AU - Timpson, Nicholas J.
AU - Bond, Tom A.
AU - Lowry, Estelle
AU - Brown, Christopher D.
AU - Estivill, Xavier
AU - Lindi, Virpi
AU - Bradfield, Jonathan P.
AU - Geller, Frank
AU - Speed, Doug
AU - Coin, Lachlan J.M.
AU - Loh, Marie
AU - Barton, Sheila J.
AU - Beilin, Lawrence J.
AU - Bisgaard, Hans
AU - Bønnelykke, Klaus
AU - Alili, Rohia
AU - Hatoum, Ida J.
AU - Schramm, Katharina
AU - Cartwright, Rufus
AU - Charles, Marie Aline
AU - Salerno, Vincenzo
AU - Clément, Karine
AU - Claringbould, Annique A.J.
AU - Van Duijn, Cornelia M.
AU - Moltchanova, Elena
AU - Eriksson, Johan G.
AU - Elks, Cathy
AU - Feenstra, Bjarke
AU - Flexeder, Claudia
AU - Franks, Stephen
AU - Frayling, Timothy M.
AU - Freathy, Rachel M.
AU - Elliott, Paul
AU - Widén, Elisabeth
AU - Hakonarson, Hakon
AU - Hattersley, Andrew T.
AU - Rodriguez, Alina
AU - Banterle, Marco
AU - Heinrich, Joachim
AU - Heude, Barbara
AU - Holloway, John W.
AU - Hofman, Albert
AU - Hyppönen, Elina
AU - Inskip, Hazel
AU - Kaplan, Lee M.
AU - Hedman, Asa K.
AU - Läärä, Esa
AU - Prokisch, Holger
AU - Grallert, Harald
AU - Lakka, Timo A.
AU - Lawlor, Debbie A.
AU - Melbye, Mads
AU - Ahluwalia, Tarunveer S.
AU - Marinelli, Marcella
AU - Millwood, Iona Y.
AU - Palmer, Lyle J.
AU - Pennell, Craig E.
AU - Perry, John R.
AU - Ring, Susan M.
AU - Savolainen, Markku J.
AU - Rivadeneira, Fernando
AU - Standl, Marie
AU - Sunyer, Jordi
AU - Tiesler, Carla M.T.
AU - Uitterlinden, Andre G.
AU - Schierding, William
AU - Sullivan, O'Justin M.
AU - Prokopenko, Inga
AU - Herzig, Karl Heinz
AU - Smith, George Davey
AU - O'Reilly, Paul
AU - Felix, Janine F.
AU - Buxton, Jessica L.
AU - Blakemore, Alexandra I.F.
AU - Ong, Ken K.
AU - Jaddoe, Vincent W.V.
AU - Grant, Struan F.A.
AU - Sebert, Sylvain
AU - McCarthy, Mark I.
AU - Järvelin, Marjo Riitta
PY - 2019/9/4
Y1 - 2019/9/4
N2 - Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
AB - Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
UR - http://www.scopus.com/inward/record.url?scp=85073762530&partnerID=8YFLogxK
U2 - 10.1126/sciadv.aaw3095
DO - 10.1126/sciadv.aaw3095
M3 - Article
C2 - 31840077
AN - SCOPUS:85073762530
SN - 2375-2548
VL - 5
JO - Science Advances
JF - Science Advances
IS - 9
M1 - eaaw3095
ER -
