GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans

G. Chittoor; J.W. Kent; M. Almeida; S. Puppala; V.S. Farook; S.A. Cole; K. Haack; H.H.H. Göring; J.W. MacCluer; J.E. Curran; M.A. Carless; M.P. Johnson; Eric K. Moses; L. Almasy; M.C. Mahaney; D.M. Lehman; R. Duggirala; A.G. Comuzzie; J. Blangero; V.S. Voruganti

doi:10.1186/s12864-016-2594-5

GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans

G. Chittoor, J.W. Kent, M. Almeida, S. Puppala, V.S. Farook, S.A. Cole, K. Haack, H.H.H. Göring, J.W. MacCluer, J.E. Curran, M.A. Carless, M.P. Johnson, Eric K. Moses, L. Almasy, M.C. Mahaney, D.M. Lehman, R. Duggirala, A.G. Comuzzie, J. Blangero, V.S. Voruganti

Centre for Genetic Origins of Health and Diseases

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

© 2016 Chittoor et al. Background: The variation in serum uric acid concentrations is under significant genetic influence. Elevated SUA concentrations have been linked to increased risk for gout, kidney stones, chronic kidney disease, and cardiovascular disease whereas reduced serum uric acid concentrations have been linked to multiple sclerosis, Parkinson's disease and Alzheimer's disease. Previously, we identified a novel locus on chromosome 3p26 affecting serum uric acid concentrations in Mexican Americans from San Antonio Family Heart Study. As a follow up, we examined genome-wide single nucleotide polymorphism data in an extended cohort of 1281 Mexican Americans from multigenerational families of the San Antonio Family Heart Study and the San Antonio Family Diabetes/Gallbladder Study. We used a linear regression-based joint linkage/association test under an additive model of allelic effect, while accounting for non-independence among family members via a kinship variance component. Results: Univariate genetic analysis indicated serum uric acid concentrations to be significant heritable (h 2=0.50±0.05, p

Original language	English
Article number	276
Journal	BMC Genomics
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12864-016-2594-5
Publication status	Published - 2 Apr 2016

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Chittoor, G., Kent, J. W., Almeida, M., Puppala, S., Farook, V. S., Cole, S. A., Haack, K., Göring, H. H. H., MacCluer, J. W., Curran, J. E., Carless, M. A., Johnson, M. P., Moses, E. K., Almasy, L., Mahaney, M. C., Lehman, D. M., Duggirala, R., Comuzzie, A. G., Blangero, J., & Voruganti, V. S. (2016). GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans. BMC Genomics, 17(1), Article 276. https://doi.org/10.1186/s12864-016-2594-5

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title = "GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans",

abstract = "{\textcopyright} 2016 Chittoor et al. Background: The variation in serum uric acid concentrations is under significant genetic influence. Elevated SUA concentrations have been linked to increased risk for gout, kidney stones, chronic kidney disease, and cardiovascular disease whereas reduced serum uric acid concentrations have been linked to multiple sclerosis, Parkinson's disease and Alzheimer's disease. Previously, we identified a novel locus on chromosome 3p26 affecting serum uric acid concentrations in Mexican Americans from San Antonio Family Heart Study. As a follow up, we examined genome-wide single nucleotide polymorphism data in an extended cohort of 1281 Mexican Americans from multigenerational families of the San Antonio Family Heart Study and the San Antonio Family Diabetes/Gallbladder Study. We used a linear regression-based joint linkage/association test under an additive model of allelic effect, while accounting for non-independence among family members via a kinship variance component. Results: Univariate genetic analysis indicated serum uric acid concentrations to be significant heritable (h 2=0.50±0.05, p",

author = "G. Chittoor and J.W. Kent and M. Almeida and S. Puppala and V.S. Farook and S.A. Cole and K. Haack and H.H.H. G{\"o}ring and J.W. MacCluer and J.E. Curran and M.A. Carless and M.P. Johnson and Moses, {Eric K.} and L. Almasy and M.C. Mahaney and D.M. Lehman and R. Duggirala and A.G. Comuzzie and J. Blangero and V.S. Voruganti",

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Chittoor, G, Kent, JW, Almeida, M, Puppala, S, Farook, VS, Cole, SA, Haack, K, Göring, HHH, MacCluer, JW, Curran, JE, Carless, MA, Johnson, MP, Moses, EK, Almasy, L, Mahaney, MC, Lehman, DM, Duggirala, R, Comuzzie, AG, Blangero, J & Voruganti, VS 2016, 'GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans', BMC Genomics, vol. 17, no. 1, 276. https://doi.org/10.1186/s12864-016-2594-5

TY - JOUR

T1 - GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans

AU - Chittoor, G.

AU - Kent, J.W.

AU - Almeida, M.

AU - Puppala, S.

AU - Farook, V.S.

AU - Cole, S.A.

AU - Haack, K.

AU - Göring, H.H.H.

AU - MacCluer, J.W.

AU - Curran, J.E.

AU - Carless, M.A.

AU - Johnson, M.P.

AU - Moses, Eric K.

AU - Almasy, L.

AU - Mahaney, M.C.

AU - Lehman, D.M.

AU - Duggirala, R.

AU - Comuzzie, A.G.

AU - Blangero, J.

AU - Voruganti, V.S.

PY - 2016/4/2

Y1 - 2016/4/2

N2 - © 2016 Chittoor et al. Background: The variation in serum uric acid concentrations is under significant genetic influence. Elevated SUA concentrations have been linked to increased risk for gout, kidney stones, chronic kidney disease, and cardiovascular disease whereas reduced serum uric acid concentrations have been linked to multiple sclerosis, Parkinson's disease and Alzheimer's disease. Previously, we identified a novel locus on chromosome 3p26 affecting serum uric acid concentrations in Mexican Americans from San Antonio Family Heart Study. As a follow up, we examined genome-wide single nucleotide polymorphism data in an extended cohort of 1281 Mexican Americans from multigenerational families of the San Antonio Family Heart Study and the San Antonio Family Diabetes/Gallbladder Study. We used a linear regression-based joint linkage/association test under an additive model of allelic effect, while accounting for non-independence among family members via a kinship variance component. Results: Univariate genetic analysis indicated serum uric acid concentrations to be significant heritable (h 2=0.50±0.05, p

AB - © 2016 Chittoor et al. Background: The variation in serum uric acid concentrations is under significant genetic influence. Elevated SUA concentrations have been linked to increased risk for gout, kidney stones, chronic kidney disease, and cardiovascular disease whereas reduced serum uric acid concentrations have been linked to multiple sclerosis, Parkinson's disease and Alzheimer's disease. Previously, we identified a novel locus on chromosome 3p26 affecting serum uric acid concentrations in Mexican Americans from San Antonio Family Heart Study. As a follow up, we examined genome-wide single nucleotide polymorphism data in an extended cohort of 1281 Mexican Americans from multigenerational families of the San Antonio Family Heart Study and the San Antonio Family Diabetes/Gallbladder Study. We used a linear regression-based joint linkage/association test under an additive model of allelic effect, while accounting for non-independence among family members via a kinship variance component. Results: Univariate genetic analysis indicated serum uric acid concentrations to be significant heritable (h 2=0.50±0.05, p

U2 - 10.1186/s12864-016-2594-5

DO - 10.1186/s12864-016-2594-5

M3 - Article

C2 - 27039371

SN - 1471-2164

VL - 17

JO - BMC Genomics

JF - BMC Genomics

IS - 1

M1 - 276

ER -

GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans

Abstract

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