Growth factors and cytokines in chronic leg ulcers

Michael Stacey, N.J. Trengove

Research output: Contribution to journalLetter

25 Citations (Scopus)

Abstract

The role of growth factors and cytokines in the impaired healing of chronic leg ulcers remains uncertain. The aim of this study was to determine whether changes in the amount and location of cytokines and growth factors may be associated with impaired healing in chronic leg ulcers. Biopsies from leg ulcers of 21 patients and from normal skin of nine healthy volunteers were examined immunohistochemically for selected growth factors and cytokines. Greater staining intensity was found in keratinocytes at the edges of ulcers compared to normal skin, or skin adjacent to the ulcers. Staining at the ulcer edge was more intense in nonhealing ulcers for only vascular endothelial growth factor and platelet-derived growth factor, whereas staining in the adjacent skin was more intense for all factors in the nonhealing phase. For all factors staining was cytoplasmic, suggesting production in these areas. This study shows upregulation of the production of cytokines and growth factors in keratinocytes of chronic leg ulcers that is greater when the ulcers are nonhealing.
Original languageEnglish
Pages (from-to)396
JournalWound Repair and Regeneration
Volume3
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Leg Ulcer
Ulcer
Intercellular Signaling Peptides and Proteins
Cytokines
Staining and Labeling
Skin
Fibroblast Growth Factor 7
Platelet-Derived Growth Factor
Keratinocytes
Vascular Endothelial Growth Factor A
Healthy Volunteers
Up-Regulation
Biopsy

Cite this

Stacey, Michael ; Trengove, N.J. / Growth factors and cytokines in chronic leg ulcers. In: Wound Repair and Regeneration. 1995 ; Vol. 3, No. 3. pp. 396.
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Growth factors and cytokines in chronic leg ulcers. / Stacey, Michael; Trengove, N.J.

In: Wound Repair and Regeneration, Vol. 3, No. 3, 1995, p. 396.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Growth factors and cytokines in chronic leg ulcers

AU - Stacey, Michael

AU - Trengove, N.J.

PY - 1995

Y1 - 1995

N2 - The role of growth factors and cytokines in the impaired healing of chronic leg ulcers remains uncertain. The aim of this study was to determine whether changes in the amount and location of cytokines and growth factors may be associated with impaired healing in chronic leg ulcers. Biopsies from leg ulcers of 21 patients and from normal skin of nine healthy volunteers were examined immunohistochemically for selected growth factors and cytokines. Greater staining intensity was found in keratinocytes at the edges of ulcers compared to normal skin, or skin adjacent to the ulcers. Staining at the ulcer edge was more intense in nonhealing ulcers for only vascular endothelial growth factor and platelet-derived growth factor, whereas staining in the adjacent skin was more intense for all factors in the nonhealing phase. For all factors staining was cytoplasmic, suggesting production in these areas. This study shows upregulation of the production of cytokines and growth factors in keratinocytes of chronic leg ulcers that is greater when the ulcers are nonhealing.

AB - The role of growth factors and cytokines in the impaired healing of chronic leg ulcers remains uncertain. The aim of this study was to determine whether changes in the amount and location of cytokines and growth factors may be associated with impaired healing in chronic leg ulcers. Biopsies from leg ulcers of 21 patients and from normal skin of nine healthy volunteers were examined immunohistochemically for selected growth factors and cytokines. Greater staining intensity was found in keratinocytes at the edges of ulcers compared to normal skin, or skin adjacent to the ulcers. Staining at the ulcer edge was more intense in nonhealing ulcers for only vascular endothelial growth factor and platelet-derived growth factor, whereas staining in the adjacent skin was more intense for all factors in the nonhealing phase. For all factors staining was cytoplasmic, suggesting production in these areas. This study shows upregulation of the production of cytokines and growth factors in keratinocytes of chronic leg ulcers that is greater when the ulcers are nonhealing.

U2 - 10.1046/j.1524-475X.2003.11502.x

DO - 10.1046/j.1524-475X.2003.11502.x

M3 - Letter

VL - 3

SP - 396

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

SN - 1067-1927

IS - 3

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