Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia

H.S. Marshall, Peter Richmond, M. Nissen, S. Lambert, R. Booy, G. Reynolds, S. Sebastian, M. Pride, K.U. Jansen, A.S. Anderson, I.L. Scully

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    © 2015 Wolters Kluwer Health, Inc. Background: Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. Methods: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody. Results: GAS-positive culture prevalence in throat swabs was 5.0% (range 0-10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (
    Original languageEnglish
    Pages (from-to)831-838
    JournalPediatric Infectious Disease Journal
    Volume34
    Issue number8
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Dive into the research topics of 'Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia'. Together they form a unique fingerprint.

    Cite this