Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia

H.S. Marshall; Peter Richmond; M. Nissen; S. Lambert; R. Booy; G. Reynolds; S. Sebastian; M. Pride; K.U. Jansen; A.S. Anderson; I.L. Scully

doi:10.1097/INF.0000000000000745

Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia

H.S. Marshall, Peter Richmond, M. Nissen, S. Lambert, R. Booy, G. Reynolds, S. Sebastian, M. Pride, K.U. Jansen, A.S. Anderson, I.L. Scully

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Abstract

© 2015 Wolters Kluwer Health, Inc. Background: Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. Methods: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody. Results: GAS-positive culture prevalence in throat swabs was 5.0% (range 0-10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (

Original language	English
Pages (from-to)	831-838
Journal	Pediatric Infectious Disease Journal
Volume	34
Issue number	8
DOIs	https://doi.org/10.1097/INF.0000000000000745
Publication status	Published - 2015

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title = "Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia",

abstract = "{\textcopyright} 2015 Wolters Kluwer Health, Inc. Background: Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. Methods: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody. Results: GAS-positive culture prevalence in throat swabs was 5.0% (range 0-10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (",

author = "H.S. Marshall and Peter Richmond and M. Nissen and S. Lambert and R. Booy and G. Reynolds and S. Sebastian and M. Pride and K.U. Jansen and A.S. Anderson and I.L. Scully",

year = "2015",

doi = "10.1097/INF.0000000000000745",

language = "English",

volume = "34",

pages = "831--838",

journal = "Pediatric Infectious Disease Journal",

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TY - JOUR

T1 - Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia

AU - Marshall, H.S.

AU - Richmond, Peter

AU - Nissen, M.

AU - Lambert, S.

AU - Booy, R.

AU - Reynolds, G.

AU - Sebastian, S.

AU - Pride, M.

AU - Jansen, K.U.

AU - Anderson, A.S.

AU - Scully, I.L.

PY - 2015

Y1 - 2015

N2 - © 2015 Wolters Kluwer Health, Inc. Background: Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. Methods: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody. Results: GAS-positive culture prevalence in throat swabs was 5.0% (range 0-10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (

AB - © 2015 Wolters Kluwer Health, Inc. Background: Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. Methods: A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody. Results: GAS-positive culture prevalence in throat swabs was 5.0% (range 0-10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (

U2 - 10.1097/INF.0000000000000745

DO - 10.1097/INF.0000000000000745

M3 - Article

SN - 0891-3668

VL - 34

SP - 831

EP - 838

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 8

ER -

Group a streptococcal carriage and seroepidemiology in children up to 10 years of age in Australia

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