Grey matter changes associated with deficit awareness in mild cognitive impairment: A voxel-based morphometry study

Andrew Ford, Osvaldo Almeida, Leon Flicker, Griselda De Garrido, Kathryn Greenop, J.K. Foster, Christopher Etherton-Beer, Frank Van Bockxmeer, Nicola Lautenschlager

Research output: Contribution to journalArticle

3 Citations (Scopus)
227 Downloads (Pure)

Abstract

© 2014-IOS Press and the authors. All rights reserved. Reduced awareness of cognitive deficits in mild cognitive impairment (MCI) is associated with poorer outcomes although little is known about the anatomical correlates of this. We examined the association of insight and grey matter volume using a voxel-based morphometry approach in 65 volunteers with MCI and 55 healthy age-matched controls. Participants with MCI had multiple areas of subtle grey matter volume loss compared with controls, although these did not survive correction for multiple comparisons. These were predominantly in the temporal and anterior portions of the brain. Individuals with MCI did not differ from each other on a number of demographic and cognitive variables according to level of insight. Reduced awareness of cognitive deficits was associated with few differences in grey matter volume apart from a subtle loss of grey matter in the medial frontal gyri. Given the modest nature of these findings, the routine assessment of insight in non-clinical populations of individuals with MCI is therefore not supported. Prospective data in larger samples, however, would be helpful to clarify this further and determine if impaired insight predicts brain atrophy and cognitive decline.
Original languageEnglish
Pages (from-to)1251-1259
JournalJournal of Alzheimer's Disease
Volume42
Issue number4
DOIs
Publication statusPublished - Jul 2014

Fingerprint

Brain
Prefrontal Cortex
Atrophy
Gray Matter
Cognitive Dysfunction
Volunteers
Demography
Population

Cite this

Ford, Andrew ; Almeida, Osvaldo ; Flicker, Leon ; De Garrido, Griselda ; Greenop, Kathryn ; Foster, J.K. ; Etherton-Beer, Christopher ; Van Bockxmeer, Frank ; Lautenschlager, Nicola. / Grey matter changes associated with deficit awareness in mild cognitive impairment: A voxel-based morphometry study. In: Journal of Alzheimer's Disease. 2014 ; Vol. 42, No. 4. pp. 1251-1259.
@article{37a258ff59c24399a84366d30e9eb71f,
title = "Grey matter changes associated with deficit awareness in mild cognitive impairment: A voxel-based morphometry study",
abstract = "{\circledC} 2014-IOS Press and the authors. All rights reserved. Reduced awareness of cognitive deficits in mild cognitive impairment (MCI) is associated with poorer outcomes although little is known about the anatomical correlates of this. We examined the association of insight and grey matter volume using a voxel-based morphometry approach in 65 volunteers with MCI and 55 healthy age-matched controls. Participants with MCI had multiple areas of subtle grey matter volume loss compared with controls, although these did not survive correction for multiple comparisons. These were predominantly in the temporal and anterior portions of the brain. Individuals with MCI did not differ from each other on a number of demographic and cognitive variables according to level of insight. Reduced awareness of cognitive deficits was associated with few differences in grey matter volume apart from a subtle loss of grey matter in the medial frontal gyri. Given the modest nature of these findings, the routine assessment of insight in non-clinical populations of individuals with MCI is therefore not supported. Prospective data in larger samples, however, would be helpful to clarify this further and determine if impaired insight predicts brain atrophy and cognitive decline.",
author = "Andrew Ford and Osvaldo Almeida and Leon Flicker and {De Garrido}, Griselda and Kathryn Greenop and J.K. Foster and Christopher Etherton-Beer and {Van Bockxmeer}, Frank and Nicola Lautenschlager",
year = "2014",
month = "7",
doi = "10.3233/JAD-132678",
language = "English",
volume = "42",
pages = "1251--1259",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "4",

}

Grey matter changes associated with deficit awareness in mild cognitive impairment: A voxel-based morphometry study. / Ford, Andrew; Almeida, Osvaldo; Flicker, Leon; De Garrido, Griselda; Greenop, Kathryn; Foster, J.K.; Etherton-Beer, Christopher; Van Bockxmeer, Frank; Lautenschlager, Nicola.

In: Journal of Alzheimer's Disease, Vol. 42, No. 4, 07.2014, p. 1251-1259.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Grey matter changes associated with deficit awareness in mild cognitive impairment: A voxel-based morphometry study

AU - Ford, Andrew

AU - Almeida, Osvaldo

AU - Flicker, Leon

AU - De Garrido, Griselda

AU - Greenop, Kathryn

AU - Foster, J.K.

AU - Etherton-Beer, Christopher

AU - Van Bockxmeer, Frank

AU - Lautenschlager, Nicola

PY - 2014/7

Y1 - 2014/7

N2 - © 2014-IOS Press and the authors. All rights reserved. Reduced awareness of cognitive deficits in mild cognitive impairment (MCI) is associated with poorer outcomes although little is known about the anatomical correlates of this. We examined the association of insight and grey matter volume using a voxel-based morphometry approach in 65 volunteers with MCI and 55 healthy age-matched controls. Participants with MCI had multiple areas of subtle grey matter volume loss compared with controls, although these did not survive correction for multiple comparisons. These were predominantly in the temporal and anterior portions of the brain. Individuals with MCI did not differ from each other on a number of demographic and cognitive variables according to level of insight. Reduced awareness of cognitive deficits was associated with few differences in grey matter volume apart from a subtle loss of grey matter in the medial frontal gyri. Given the modest nature of these findings, the routine assessment of insight in non-clinical populations of individuals with MCI is therefore not supported. Prospective data in larger samples, however, would be helpful to clarify this further and determine if impaired insight predicts brain atrophy and cognitive decline.

AB - © 2014-IOS Press and the authors. All rights reserved. Reduced awareness of cognitive deficits in mild cognitive impairment (MCI) is associated with poorer outcomes although little is known about the anatomical correlates of this. We examined the association of insight and grey matter volume using a voxel-based morphometry approach in 65 volunteers with MCI and 55 healthy age-matched controls. Participants with MCI had multiple areas of subtle grey matter volume loss compared with controls, although these did not survive correction for multiple comparisons. These were predominantly in the temporal and anterior portions of the brain. Individuals with MCI did not differ from each other on a number of demographic and cognitive variables according to level of insight. Reduced awareness of cognitive deficits was associated with few differences in grey matter volume apart from a subtle loss of grey matter in the medial frontal gyri. Given the modest nature of these findings, the routine assessment of insight in non-clinical populations of individuals with MCI is therefore not supported. Prospective data in larger samples, however, would be helpful to clarify this further and determine if impaired insight predicts brain atrophy and cognitive decline.

U2 - 10.3233/JAD-132678

DO - 10.3233/JAD-132678

M3 - Article

VL - 42

SP - 1251

EP - 1259

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 4

ER -