Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men

Lauren C. Chasland, Matthew W. Knuiman, Mark L. Divitini, Yi X. Chan, David J. Handelsman, Louise H. Naylor, Daniel J. Green, Bu B. Yeap

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Abstract

Context: Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear. Objective: We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk. Participants: A total of 1649 men. Methods: Leisure, home, work and total PA were ascertained. At baseline, serum T, dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Men were stratified into high PA+high hormone (H/H); low PA+high hormone (L/H); high PA+low hormone (H/L); and low PA+low hormone (L/L). Results: Mean age was 49.8 years at outset with 415 CVD events and 127 CVD deaths occurring during 20-year follow-up. Men with higher PA and higher T or DHT had lower odds of metabolic syndrome (eg leisure H/H vs L/L odds ratio [OR] 0.17 P<.001 for T, 0.26 P<.001 for DHT). Men with higher PA and E2 had lower risk of metabolic syndrome (eg leisure PA H/H vs L/L OR 0.51, P=.001). Men with higher leisure, work or total PA and higher DHT had the lowest risk of CVD death (eg leisure H/H hazard ratio [HR] 0.55 vs L/L, P=.033). Men with lower leisure, home or work PA and higher E2 were at greater risk of CVD death (eg leisure L/H HR 1.60 vs L/L, P=.039). Conclusions: Considering T, DHT and E2 in the context of PA better informs consideration of cardiovascular risk. A 2×2 factorial RCT assessing PA and androgens would illuminate the scope for preventing CVD in men.

Original languageEnglish
Pages (from-to)466-474
JournalClinical Endocrinology
Volume87
Issue number5
DOIs
Publication statusPublished - Nov 2017

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Androgens
Exercise
Leisure Activities
Cardiovascular Diseases
Dihydrotestosterone
Hormones
Odds Ratio
Gonadal Steroid Hormones
Testosterone
Estradiol

Cite this

@article{53fe61d6066f4f9380f5b554c22df897,
title = "Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men",
abstract = "Context: Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear. Objective: We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk. Participants: A total of 1649 men. Methods: Leisure, home, work and total PA were ascertained. At baseline, serum T, dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Men were stratified into high PA+high hormone (H/H); low PA+high hormone (L/H); high PA+low hormone (H/L); and low PA+low hormone (L/L). Results: Mean age was 49.8 years at outset with 415 CVD events and 127 CVD deaths occurring during 20-year follow-up. Men with higher PA and higher T or DHT had lower odds of metabolic syndrome (eg leisure H/H vs L/L odds ratio [OR] 0.17 P<.001 for T, 0.26 P<.001 for DHT). Men with higher PA and E2 had lower risk of metabolic syndrome (eg leisure PA H/H vs L/L OR 0.51, P=.001). Men with higher leisure, work or total PA and higher DHT had the lowest risk of CVD death (eg leisure H/H hazard ratio [HR] 0.55 vs L/L, P=.033). Men with lower leisure, home or work PA and higher E2 were at greater risk of CVD death (eg leisure L/H HR 1.60 vs L/L, P=.039). Conclusions: Considering T, DHT and E2 in the context of PA better informs consideration of cardiovascular risk. A 2×2 factorial RCT assessing PA and androgens would illuminate the scope for preventing CVD in men.",
keywords = "Cardiovascular disease, Metabolic syndrome, Physical activity, Testosterone",
author = "Chasland, {Lauren C.} and Knuiman, {Matthew W.} and Divitini, {Mark L.} and Chan, {Yi X.} and Handelsman, {David J.} and Naylor, {Louise H.} and Green, {Daniel J.} and Yeap, {Bu B.}",
year = "2017",
month = "11",
doi = "10.1111/cen.13407",
language = "English",
volume = "87",
pages = "466--474",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "John Wiley & Sons",
number = "5",

}

TY - JOUR

T1 - Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men

AU - Chasland, Lauren C.

AU - Knuiman, Matthew W.

AU - Divitini, Mark L.

AU - Chan, Yi X.

AU - Handelsman, David J.

AU - Naylor, Louise H.

AU - Green, Daniel J.

AU - Yeap, Bu B.

PY - 2017/11

Y1 - 2017/11

N2 - Context: Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear. Objective: We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk. Participants: A total of 1649 men. Methods: Leisure, home, work and total PA were ascertained. At baseline, serum T, dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Men were stratified into high PA+high hormone (H/H); low PA+high hormone (L/H); high PA+low hormone (H/L); and low PA+low hormone (L/L). Results: Mean age was 49.8 years at outset with 415 CVD events and 127 CVD deaths occurring during 20-year follow-up. Men with higher PA and higher T or DHT had lower odds of metabolic syndrome (eg leisure H/H vs L/L odds ratio [OR] 0.17 P<.001 for T, 0.26 P<.001 for DHT). Men with higher PA and E2 had lower risk of metabolic syndrome (eg leisure PA H/H vs L/L OR 0.51, P=.001). Men with higher leisure, work or total PA and higher DHT had the lowest risk of CVD death (eg leisure H/H hazard ratio [HR] 0.55 vs L/L, P=.033). Men with lower leisure, home or work PA and higher E2 were at greater risk of CVD death (eg leisure L/H HR 1.60 vs L/L, P=.039). Conclusions: Considering T, DHT and E2 in the context of PA better informs consideration of cardiovascular risk. A 2×2 factorial RCT assessing PA and androgens would illuminate the scope for preventing CVD in men.

AB - Context: Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear. Objective: We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk. Participants: A total of 1649 men. Methods: Leisure, home, work and total PA were ascertained. At baseline, serum T, dihydrotestosterone (DHT) and oestradiol (E2) were assayed. Men were stratified into high PA+high hormone (H/H); low PA+high hormone (L/H); high PA+low hormone (H/L); and low PA+low hormone (L/L). Results: Mean age was 49.8 years at outset with 415 CVD events and 127 CVD deaths occurring during 20-year follow-up. Men with higher PA and higher T or DHT had lower odds of metabolic syndrome (eg leisure H/H vs L/L odds ratio [OR] 0.17 P<.001 for T, 0.26 P<.001 for DHT). Men with higher PA and E2 had lower risk of metabolic syndrome (eg leisure PA H/H vs L/L OR 0.51, P=.001). Men with higher leisure, work or total PA and higher DHT had the lowest risk of CVD death (eg leisure H/H hazard ratio [HR] 0.55 vs L/L, P=.033). Men with lower leisure, home or work PA and higher E2 were at greater risk of CVD death (eg leisure L/H HR 1.60 vs L/L, P=.039). Conclusions: Considering T, DHT and E2 in the context of PA better informs consideration of cardiovascular risk. A 2×2 factorial RCT assessing PA and androgens would illuminate the scope for preventing CVD in men.

KW - Cardiovascular disease

KW - Metabolic syndrome

KW - Physical activity

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85026393041&partnerID=8YFLogxK

U2 - 10.1111/cen.13407

DO - 10.1111/cen.13407

M3 - Article

VL - 87

SP - 466

EP - 474

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 5

ER -