Granulosa cell apoptosis in the ovarian follicle-A changing view

Sheena L.P. Regan; Phil G. Knight; John L. Yovich; Yee Leung; Frank Arfuso; Arun Dharmarajan

doi:10.3389/fendo.2018.00061

Granulosa cell apoptosis in the ovarian follicle-A changing view

Sheena L.P. Regan, Phil G. Knight, John L. Yovich, Yee Leung, Frank Arfuso, Arun Dharmarajan

Research output: Contribution to journal › Review article › peer-review

153 Citations (Scopus)

Abstract

Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

Original language	English
Article number	61
Journal	Frontiers in Endocrinology
Volume	9
Issue number	MAR
DOIs	https://doi.org/10.3389/fendo.2018.00061
Publication status	Published - 2 Mar 2018
Externally published	Yes

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10.3389/fendo.2018.00061Licence: CC BY

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title = "Granulosa cell apoptosis in the ovarian follicle-A changing view",

abstract = "Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.",

keywords = "Aging effects, Apoptosis signaling, Bone morphogenetic proteins, Fertility preservation, Mitogenic growth, Ovarian reserve, Receptor of follicle stimulating hormone",

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AU - Regan, Sheena L.P.

AU - Knight, Phil G.

AU - Yovich, John L.

AU - Leung, Yee

AU - Arfuso, Frank

AU - Dharmarajan, Arun

PY - 2018/3/2

Y1 - 2018/3/2

N2 - Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

AB - Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

KW - Aging effects

KW - Apoptosis signaling

KW - Bone morphogenetic proteins

KW - Fertility preservation

KW - Mitogenic growth

KW - Ovarian reserve

KW - Receptor of follicle stimulating hormone

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DO - 10.3389/fendo.2018.00061

M3 - Review article

AN - SCOPUS:85042793488

SN - 1664-2392

VL - 9

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

IS - MAR

M1 - 61

ER -

Granulosa cell apoptosis in the ovarian follicle-A changing view

Abstract

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