Granulosa cell apoptosis in the ovarian follicle-A changing view

Sheena L.P. Regan, Phil G. Knight, John L. Yovich, Yee Leung, Frank Arfuso, Arun Dharmarajan

Research output: Contribution to journalReview articlepeer-review

61 Citations (Scopus)


Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

Original languageEnglish
Article number61
JournalFrontiers in Endocrinology
Issue numberMAR
Publication statusPublished - 2 Mar 2018
Externally publishedYes


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