Granulosa cell apoptosis in the ovarian follicle-A changing view

Sheena L.P. Regan, Phil G. Knight, John L. Yovich, Yee Leung, Frank Arfuso, Arun Dharmarajan

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

Original languageEnglish
Article number61
JournalFrontiers in Endocrinology
Volume9
Issue numberMAR
DOIs
Publication statusPublished - 2 Mar 2018
Externally publishedYes

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Ovarian Follicle
Granulosa Cells
Apoptosis
Oocytes
Pregnancy Rate
Fertilization in Vitro
Phenotype

Cite this

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Granulosa cell apoptosis in the ovarian follicle-A changing view. / Regan, Sheena L.P.; Knight, Phil G.; Yovich, John L.; Leung, Yee; Arfuso, Frank; Dharmarajan, Arun.

In: Frontiers in Endocrinology, Vol. 9, No. MAR, 61, 02.03.2018.

Research output: Contribution to journalReview article

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T1 - Granulosa cell apoptosis in the ovarian follicle-A changing view

AU - Regan, Sheena L.P.

AU - Knight, Phil G.

AU - Yovich, John L.

AU - Leung, Yee

AU - Arfuso, Frank

AU - Dharmarajan, Arun

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KW - Apoptosis signaling

KW - Bone morphogenetic proteins

KW - Fertility preservation

KW - Mitogenic growth

KW - Ovarian reserve

KW - Receptor of follicle stimulating hormone

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