Graded ephrin-A2 expression in the developing hamster superior colliculus

Sherralee Lukehurst, C. King, Lyn Beazley, D.K.C. Tay, K.F. So, Jennifer Rodger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostral(low) to caudal(high) gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.
Original languageEnglish
Pages (from-to)546-552
JournalExperimental Brain Research
Volume173
Issue number3
DOIs
Publication statusPublished - 2006

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