TY - JOUR
T1 - Graded ephrin-A2 expression in the developing hamster superior colliculus
AU - Lukehurst, Sherralee
AU - King, C.
AU - Beazley, Lyn
AU - Tay, D.K.C.
AU - So, K.F.
AU - Rodger, Jennifer
PY - 2006
Y1 - 2006
N2 - During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostral(low) to caudal(high) gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.
AB - During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostral(low) to caudal(high) gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.
U2 - 10.1007/s00221-006-0615-3
DO - 10.1007/s00221-006-0615-3
M3 - Article
C2 - 16850319
SN - 0014-4819
VL - 173
SP - 546
EP - 552
JO - Experimental Brain Research
JF - Experimental Brain Research
IS - 3
ER -