GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

Stephen G. Young, Loren G. Fong, Anne P. Beigneux, Christopher M. Allan, Cuiwen He, Haibo Jiang, Katsuyuki Nakajima, Muthuraman Meiyappan, Gabriel Birrane, Michael Ploug

Research output: Contribution to journalReview article

Abstract

Lipoprotein lipase (LPL), identified in the 1950s, has been studied intensively by biochemists, physiologists, and clinical investigators. These efforts uncovered a central role for LPL in plasma triglyceride metabolism and identified LPL mutations as a cause of hypertriglyceridemia. By the 1990s, with an outline for plasma triglyceride metabolism established, interest in triglyceride metabolism waned. In recent years, however, interest in plasma triglyceride metabolism has awakened, in part because of the discovery of new molecules governing triglyceride metabolism. One such protein—and the focus of this review—is GPIHBP1, a protein of capillary endothelial cells. GPIHBP1 is LPL's essential partner: it binds LPL and transports it to the capillary lumen; it is essential for lipoprotein margination along capillaries, allowing lipolysis to proceed; and it preserves LPL's structure and activity. Recently, GPIHBP1 was the key to solving the structure of LPL. These developments have transformed the models for intravascular triglyceride metabolism.

Original languageEnglish
Pages (from-to)51-65
Number of pages15
JournalCell Metabolism
Volume30
Issue number1
DOIs
Publication statusPublished - 2 Jul 2019

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Lipoprotein Lipase
Triglycerides
Hypertriglyceridemia
Lipolysis
Lipoproteins
Endothelial Cells
Research Personnel
Mutation
Proteins

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Young, S. G., Fong, L. G., Beigneux, A. P., Allan, C. M., He, C., Jiang, H., ... Ploug, M. (2019). GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metabolism, 30(1), 51-65. https://doi.org/10.1016/j.cmet.2019.05.023
Young, Stephen G. ; Fong, Loren G. ; Beigneux, Anne P. ; Allan, Christopher M. ; He, Cuiwen ; Jiang, Haibo ; Nakajima, Katsuyuki ; Meiyappan, Muthuraman ; Birrane, Gabriel ; Ploug, Michael. / GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. In: Cell Metabolism. 2019 ; Vol. 30, No. 1. pp. 51-65.
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abstract = "Lipoprotein lipase (LPL), identified in the 1950s, has been studied intensively by biochemists, physiologists, and clinical investigators. These efforts uncovered a central role for LPL in plasma triglyceride metabolism and identified LPL mutations as a cause of hypertriglyceridemia. By the 1990s, with an outline for plasma triglyceride metabolism established, interest in triglyceride metabolism waned. In recent years, however, interest in plasma triglyceride metabolism has awakened, in part because of the discovery of new molecules governing triglyceride metabolism. One such protein—and the focus of this review—is GPIHBP1, a protein of capillary endothelial cells. GPIHBP1 is LPL's essential partner: it binds LPL and transports it to the capillary lumen; it is essential for lipoprotein margination along capillaries, allowing lipolysis to proceed; and it preserves LPL's structure and activity. Recently, GPIHBP1 was the key to solving the structure of LPL. These developments have transformed the models for intravascular triglyceride metabolism.",
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Young, SG, Fong, LG, Beigneux, AP, Allan, CM, He, C, Jiang, H, Nakajima, K, Meiyappan, M, Birrane, G & Ploug, M 2019, 'GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism' Cell Metabolism, vol. 30, no. 1, pp. 51-65. https://doi.org/10.1016/j.cmet.2019.05.023

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. / Young, Stephen G.; Fong, Loren G.; Beigneux, Anne P.; Allan, Christopher M.; He, Cuiwen; Jiang, Haibo; Nakajima, Katsuyuki; Meiyappan, Muthuraman; Birrane, Gabriel; Ploug, Michael.

In: Cell Metabolism, Vol. 30, No. 1, 02.07.2019, p. 51-65.

Research output: Contribution to journalReview article

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AU - Young, Stephen G.

AU - Fong, Loren G.

AU - Beigneux, Anne P.

AU - Allan, Christopher M.

AU - He, Cuiwen

AU - Jiang, Haibo

AU - Nakajima, Katsuyuki

AU - Meiyappan, Muthuraman

AU - Birrane, Gabriel

AU - Ploug, Michael

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AB - Lipoprotein lipase (LPL), identified in the 1950s, has been studied intensively by biochemists, physiologists, and clinical investigators. These efforts uncovered a central role for LPL in plasma triglyceride metabolism and identified LPL mutations as a cause of hypertriglyceridemia. By the 1990s, with an outline for plasma triglyceride metabolism established, interest in triglyceride metabolism waned. In recent years, however, interest in plasma triglyceride metabolism has awakened, in part because of the discovery of new molecules governing triglyceride metabolism. One such protein—and the focus of this review—is GPIHBP1, a protein of capillary endothelial cells. GPIHBP1 is LPL's essential partner: it binds LPL and transports it to the capillary lumen; it is essential for lipoprotein margination along capillaries, allowing lipolysis to proceed; and it preserves LPL's structure and activity. Recently, GPIHBP1 was the key to solving the structure of LPL. These developments have transformed the models for intravascular triglyceride metabolism.

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