GPCR Signaling and Trafficking: The Long and Short of It

Nathan J. Pavlos, Peter A. Friedman

Research output: Contribution to journalReview articlepeer-review

139 Citations (Scopus)
253 Downloads (Pure)


Emerging findings disclose unexpected components of G protein-coupled receptor (GPCR) signaling and cell biology. Select GPCRs exhibit classical signaling, that is restricted to cell membranes, as well as newly described persistent signaling that depends on internalization of the GPCR bound to β-arrestins. Termination of non-canonical endosomal signaling requires intraluminal acidification and sophisticated protein trafficking machineries. Recent studies reveal the structural determinants of the trafficking chaperones. This review summarizes advances in GPCR signaling and trafficking with a focus on the parathyroid hormone receptor (PTHR) as a prototype, and on the actin–sorting nexin 27 (SNX27)–retromer tubule (ASRT) complex, an endosomal sorting hub responsible for recycling and preservation of cell surface receptors. The findings are integrated into a model of PTHR trafficking with implications for signal transduction, bone growth, and mineral ion metabolism.

Original languageEnglish
Pages (from-to)213-226
Number of pages14
JournalTrends in Endocrinology and Metabolism
Issue number3
Publication statusPublished - 1 Mar 2017


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