GORK Channel: A Master Switch of Plant Metabolism?

Getnet D. Adem, Guang Chen, Lana Shabala, Zhong Hua Chen, Sergey Shabala

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)


Potassium regulates a plethora of metabolic and developmental response in plants, and upon exposure to biotic and abiotic stresses a substantial K+ loss occurs from plant cells. The outward-rectifying potassium efflux GORK channels are central to this stress-induced K+ loss from the cytosol. In the mammalian systems, signaling molecules such as gamma-aminobutyric acid, G-proteins, ATP, inositol, and protein phosphatases were shown to operate as ligands controlling many K+ efflux channels. Here we present the evidence that the same molecules may also regulate GORK channels in plants. This mechanism enables operation of the GORK channels as a master switch of the cell metabolism, thus adjusting intracellular K+ homeostasis to altered environmental conditions, to maximize plant adaptive potential.

Original languageEnglish
Pages (from-to)434-445
Number of pages12
JournalTrends in Plant Science
Issue number5
Publication statusPublished - May 2020
Externally publishedYes


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