TY - JOUR
T1 - Gold nanoparticles
T2 - Multifaceted roles in the management of autoimmune disorders
AU - Koushki, Khadijeh
AU - Shahbaz, Sanaz Keshavarz
AU - Keshavarz, Mohsen
AU - Bezsonov, Evgeny E.
AU - Sathyapalan, Thozhukat
AU - Sahebkar, Amirhossein
PY - 2021/9
Y1 - 2021/9
N2 - Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.
AB - Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.
KW - Autoimmune diseases
KW - Gold nanoparticles
KW - Immunomodulatory effects
KW - Nanomedicine
UR - http://www.scopus.com/inward/record.url?scp=85113905327&partnerID=8YFLogxK
U2 - 10.3390/biom11091289
DO - 10.3390/biom11091289
M3 - Review article
C2 - 34572503
AN - SCOPUS:85113905327
SN - 2218-273X
VL - 11
JO - Biomolecules
JF - Biomolecules
IS - 9
M1 - 1289
ER -
