Glycated hemoglobin measurement and prediction of cardiovascular disease

E. Di Angelantonio, P. Gao, H. Khan, A.S. Butterworth, D. Wormser, S.K. Kaptoge, S.R. Kondapally Seshasai, A. Thompson, N. Sarwar, P. Willeit, P.M. Ridker, E.L.M. Barr, K.T.T. Khaw, B.M. Psaty, H. Brenner, B.J. Balkau, J.M. Dekker, D.A. Lawlor, M. Daimon, J. WilleitI. Njølstad, A.M. Nissinen, E.J. Brunner, L.H. Kuller, J.F. Price, J. Sundström, Matthew Knuiman, E.J.M. Feskens, W.M.M. Verschuren, N.J. Wald, S.J.L. Bakker, P.H. Whincup, I. Ford, U. Goldbourt, A. Gómez De La Cámara, J.E.J. Gallacher, L.A. Simons, A. Rosengren, S.E. Sutherland, C.V. Björkelund, D.G. Blazer, S.M. Wassertheil-Smoller, A. Onat, A. Marín Ibáñez, E. Casiglia, J.W. Jukema, L.M. Simpson, S. Giampaoli, B.G. Nørdestgaard, R.M. Selmer, P. Wennberg, J. Kauhanen, J.T. Salonen, R.S. Dankner, E.L. Barrett- Connor, M. Kavousi, V.G. Gudnason, D.A. Evans, R.B. Wallace, M. Cushman, R.B. D'Agostino, J.G. Umans, Y. Kiyohara, H. Nakagawa, S. Sato, R.F. Gillum, A.R. Folsom, Y.T. Van Der Schouw, K.G.M. Moons, S.J. Griffin, N.A. Sattar, N.J. Wareham, E. Selvin, S.G. Thompson, J.N. Danesh

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Abstract

IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA 1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN, SETTING, AND PARTICIPANTS: Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES: Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (
Original languageEnglish
Pages (from-to)1225-1233
JournalJAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Volume311
Issue number12
DOIs
Publication statusPublished - 2014

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