Glycated hemoglobin measurement and prediction of cardiovascular disease

E. Di Angelantonio, P. Gao, H. Khan, A.S. Butterworth, D. Wormser, S.K. Kaptoge, S.R. Kondapally Seshasai, A. Thompson, N. Sarwar, P. Willeit, P.M. Ridker, E.L.M. Barr, K.T.T. Khaw, B.M. Psaty, H. Brenner, B.J. Balkau, J.M. Dekker, D.A. Lawlor, M. Daimon, J. Willeit & 55 others I. Njølstad, A.M. Nissinen, E.J. Brunner, L.H. Kuller, J.F. Price, J. Sundström, Matthew Knuiman, E.J.M. Feskens, W.M.M. Verschuren, N.J. Wald, S.J.L. Bakker, P.H. Whincup, I. Ford, U. Goldbourt, A. Gómez De La Cámara, J.E.J. Gallacher, L.A. Simons, A. Rosengren, S.E. Sutherland, C.V. Björkelund, D.G. Blazer, S.M. Wassertheil-Smoller, A. Onat, A. Marín Ibáñez, E. Casiglia, J.W. Jukema, L.M. Simpson, S. Giampaoli, B.G. Nørdestgaard, R.M. Selmer, P. Wennberg, J. Kauhanen, J.T. Salonen, R.S. Dankner, E.L. Barrett- Connor, M. Kavousi, V.G. Gudnason, D.A. Evans, R.B. Wallace, M. Cushman, R.B. D'Agostino, J.G. Umans, Y. Kiyohara, H. Nakagawa, S. Sato, R.F. Gillum, A.R. Folsom, Y.T. Van Der Schouw, K.G.M. Moons, S.J. Griffin, N.A. Sattar, N.J. Wareham, E. Selvin, S.G. Thompson, J.N. Danesh

Research output: Contribution to journalArticle

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Abstract

IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA 1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN, SETTING, AND PARTICIPANTS: Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES: Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (
Original languageEnglish
Pages (from-to)1225-1233
JournalJAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Volume311
Issue number12
DOIs
Publication statusPublished - 2014

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Glycosylated Hemoglobin A
Cardiovascular Diseases
Diabetes Mellitus
Prospective Studies

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Di Angelantonio, E., Gao, P., Khan, H., Butterworth, A. S., Wormser, D., Kaptoge, S. K., ... Danesh, J. N. (2014). Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 311(12), 1225-1233. https://doi.org/10.1001/jama.2014.1873
Di Angelantonio, E. ; Gao, P. ; Khan, H. ; Butterworth, A.S. ; Wormser, D. ; Kaptoge, S.K. ; Kondapally Seshasai, S.R. ; Thompson, A. ; Sarwar, N. ; Willeit, P. ; Ridker, P.M. ; Barr, E.L.M. ; Khaw, K.T.T. ; Psaty, B.M. ; Brenner, H. ; Balkau, B.J. ; Dekker, J.M. ; Lawlor, D.A. ; Daimon, M. ; Willeit, J. ; Njølstad, I. ; Nissinen, A.M. ; Brunner, E.J. ; Kuller, L.H. ; Price, J.F. ; Sundström, J. ; Knuiman, Matthew ; Feskens, E.J.M. ; Verschuren, W.M.M. ; Wald, N.J. ; Bakker, S.J.L. ; Whincup, P.H. ; Ford, I. ; Goldbourt, U. ; Gómez De La Cámara, A. ; Gallacher, J.E.J. ; Simons, L.A. ; Rosengren, A. ; Sutherland, S.E. ; Björkelund, C.V. ; Blazer, D.G. ; Wassertheil-Smoller, S.M. ; Onat, A. ; Marín Ibáñez, A. ; Casiglia, E. ; Jukema, J.W. ; Simpson, L.M. ; Giampaoli, S. ; Nørdestgaard, B.G. ; Selmer, R.M. ; Wennberg, P. ; Kauhanen, J. ; Salonen, J.T. ; Dankner, R.S. ; Barrett- Connor, E.L. ; Kavousi, M. ; Gudnason, V.G. ; Evans, D.A. ; Wallace, R.B. ; Cushman, M. ; D'Agostino, R.B. ; Umans, J.G. ; Kiyohara, Y. ; Nakagawa, H. ; Sato, S. ; Gillum, R.F. ; Folsom, A.R. ; Van Der Schouw, Y.T. ; Moons, K.G.M. ; Griffin, S.J. ; Sattar, N.A. ; Wareham, N.J. ; Selvin, E. ; Thompson, S.G. ; Danesh, J.N. / Glycated hemoglobin measurement and prediction of cardiovascular disease. In: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2014 ; Vol. 311, No. 12. pp. 1225-1233.
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Di Angelantonio, E, Gao, P, Khan, H, Butterworth, AS, Wormser, D, Kaptoge, SK, Kondapally Seshasai, SR, Thompson, A, Sarwar, N, Willeit, P, Ridker, PM, Barr, ELM, Khaw, KTT, Psaty, BM, Brenner, H, Balkau, BJ, Dekker, JM, Lawlor, DA, Daimon, M, Willeit, J, Njølstad, I, Nissinen, AM, Brunner, EJ, Kuller, LH, Price, JF, Sundström, J, Knuiman, M, Feskens, EJM, Verschuren, WMM, Wald, NJ, Bakker, SJL, Whincup, PH, Ford, I, Goldbourt, U, Gómez De La Cámara, A, Gallacher, JEJ, Simons, LA, Rosengren, A, Sutherland, SE, Björkelund, CV, Blazer, DG, Wassertheil-Smoller, SM, Onat, A, Marín Ibáñez, A, Casiglia, E, Jukema, JW, Simpson, LM, Giampaoli, S, Nørdestgaard, BG, Selmer, RM, Wennberg, P, Kauhanen, J, Salonen, JT, Dankner, RS, Barrett- Connor, EL, Kavousi, M, Gudnason, VG, Evans, DA, Wallace, RB, Cushman, M, D'Agostino, RB, Umans, JG, Kiyohara, Y, Nakagawa, H, Sato, S, Gillum, RF, Folsom, AR, Van Der Schouw, YT, Moons, KGM, Griffin, SJ, Sattar, NA, Wareham, NJ, Selvin, E, Thompson, SG & Danesh, JN 2014, 'Glycated hemoglobin measurement and prediction of cardiovascular disease' JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 311, no. 12, pp. 1225-1233. https://doi.org/10.1001/jama.2014.1873

Glycated hemoglobin measurement and prediction of cardiovascular disease. / Di Angelantonio, E.; Gao, P.; Khan, H.; Butterworth, A.S.; Wormser, D.; Kaptoge, S.K.; Kondapally Seshasai, S.R.; Thompson, A.; Sarwar, N.; Willeit, P.; Ridker, P.M.; Barr, E.L.M.; Khaw, K.T.T.; Psaty, B.M.; Brenner, H.; Balkau, B.J.; Dekker, J.M.; Lawlor, D.A.; Daimon, M.; Willeit, J.; Njølstad, I.; Nissinen, A.M.; Brunner, E.J.; Kuller, L.H.; Price, J.F.; Sundström, J.; Knuiman, Matthew; Feskens, E.J.M.; Verschuren, W.M.M.; Wald, N.J.; Bakker, S.J.L.; Whincup, P.H.; Ford, I.; Goldbourt, U.; Gómez De La Cámara, A.; Gallacher, J.E.J.; Simons, L.A.; Rosengren, A.; Sutherland, S.E.; Björkelund, C.V.; Blazer, D.G.; Wassertheil-Smoller, S.M.; Onat, A.; Marín Ibáñez, A.; Casiglia, E.; Jukema, J.W.; Simpson, L.M.; Giampaoli, S.; Nørdestgaard, B.G.; Selmer, R.M.; Wennberg, P.; Kauhanen, J.; Salonen, J.T.; Dankner, R.S.; Barrett- Connor, E.L.; Kavousi, M.; Gudnason, V.G.; Evans, D.A.; Wallace, R.B.; Cushman, M.; D'Agostino, R.B.; Umans, J.G.; Kiyohara, Y.; Nakagawa, H.; Sato, S.; Gillum, R.F.; Folsom, A.R.; Van Der Schouw, Y.T.; Moons, K.G.M.; Griffin, S.J.; Sattar, N.A.; Wareham, N.J.; Selvin, E.; Thompson, S.G.; Danesh, J.N.

In: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol. 311, No. 12, 2014, p. 1225-1233.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glycated hemoglobin measurement and prediction of cardiovascular disease

AU - Di Angelantonio, E.

AU - Gao, P.

AU - Khan, H.

AU - Butterworth, A.S.

AU - Wormser, D.

AU - Kaptoge, S.K.

AU - Kondapally Seshasai, S.R.

AU - Thompson, A.

AU - Sarwar, N.

AU - Willeit, P.

AU - Ridker, P.M.

AU - Barr, E.L.M.

AU - Khaw, K.T.T.

AU - Psaty, B.M.

AU - Brenner, H.

AU - Balkau, B.J.

AU - Dekker, J.M.

AU - Lawlor, D.A.

AU - Daimon, M.

AU - Willeit, J.

AU - Njølstad, I.

AU - Nissinen, A.M.

AU - Brunner, E.J.

AU - Kuller, L.H.

AU - Price, J.F.

AU - Sundström, J.

AU - Knuiman, Matthew

AU - Feskens, E.J.M.

AU - Verschuren, W.M.M.

AU - Wald, N.J.

AU - Bakker, S.J.L.

AU - Whincup, P.H.

AU - Ford, I.

AU - Goldbourt, U.

AU - Gómez De La Cámara, A.

AU - Gallacher, J.E.J.

AU - Simons, L.A.

AU - Rosengren, A.

AU - Sutherland, S.E.

AU - Björkelund, C.V.

AU - Blazer, D.G.

AU - Wassertheil-Smoller, S.M.

AU - Onat, A.

AU - Marín Ibáñez, A.

AU - Casiglia, E.

AU - Jukema, J.W.

AU - Simpson, L.M.

AU - Giampaoli, S.

AU - Nørdestgaard, B.G.

AU - Selmer, R.M.

AU - Wennberg, P.

AU - Kauhanen, J.

AU - Salonen, J.T.

AU - Dankner, R.S.

AU - Barrett- Connor, E.L.

AU - Kavousi, M.

AU - Gudnason, V.G.

AU - Evans, D.A.

AU - Wallace, R.B.

AU - Cushman, M.

AU - D'Agostino, R.B.

AU - Umans, J.G.

AU - Kiyohara, Y.

AU - Nakagawa, H.

AU - Sato, S.

AU - Gillum, R.F.

AU - Folsom, A.R.

AU - Van Der Schouw, Y.T.

AU - Moons, K.G.M.

AU - Griffin, S.J.

AU - Sattar, N.A.

AU - Wareham, N.J.

AU - Selvin, E.

AU - Thompson, S.G.

AU - Danesh, J.N.

PY - 2014

Y1 - 2014

N2 - IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA 1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN, SETTING, AND PARTICIPANTS: Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES: Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (

AB - IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA 1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN, SETTING, AND PARTICIPANTS: Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES: Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (

U2 - 10.1001/jama.2014.1873

DO - 10.1001/jama.2014.1873

M3 - Article

VL - 311

SP - 1225

EP - 1233

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

SN - 0098-7484

IS - 12

ER -

Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge SK et al. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2014;311(12):1225-1233. https://doi.org/10.1001/jama.2014.1873