Glucagon stimulation of dna synthesis in neonatal rat liver. Studies on enzymes of dna synthesis

G. C.T. Yeoh, I. T. Oliver

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

1. 1. Glucagon (75 μg. per ml.) stimulates the incorporation of [3H]thymidine and [3H]TTP into DNA. 2. 2. Thymidine kinase, thymidine monophosphate nucleotidase, and DNA polymerase are unaffected by pretreatment of liver preparations with glucagon. 3. 3. Evidence is presented for the existence of terminal deoxynucleotidyl transferase activity in foetal rat liver. 4. 4. The development of DNA polymerase and terminal transferase is presented as a function of age. 5. 5. Glucagon stimulation of terminal transferase activity can account for the increase in [3H]dT and [3H]TTP incorporation observed under the influence of the hormone.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalInternational Journal of Biochemistry
Volume3
Issue number13
DOIs
Publication statusPublished - Feb 1972

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