Global Stability of Epidemic Models with Imperfect Vaccination and Quarantine on Scale-Free Networks

Shanshan Chen, Michael Small, Xinchu Fu

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Public health services are constantly searching for ways to reduce the spread of infectious diseases, such as public vaccination of asymptomatic individuals, quarantine and treatment of symptomatic individuals. In this paper, we introduce epidemic models including variable population size, degree-related imperfect vaccination and quarantine on scale-free networks. More specifically, the models are formulated both on the population with and without permanent natural immunity to infection, which corresponds respectively to the susceptible-vaccinated-infected-quarantined-recovered (SVIQR) model and the susceptible-vaccinated-infected-quarantined (SVIQS) model. We develop different mathematical methods to study the dynamics of two models, including the basic reproduction number, the global stability of disease-free and endemic equilibria. For the SVIQR model, we show that the system exhibits a forward bifurcation. Meanwhile, the disease-free and unique endemic equilibria are shown to be globally asymptotically stable by constructing suitable Lyapunov functions. For the SVIQS model, conditions ensuring the occurrence of multiple endemic equilibria are derived. Under certain conditions, this system cannot undergo a backward bifurcation. The global asymptotical stability of disease-free equilibrium, and the persistence of the disease are proved. The endemic equilibrium is shown to be globally attractive by using monotone iterative technique. Finally, stochastic network simulations yield quantitative agreement with the deterministic mean-field approach.

Original languageEnglish
Article number8844772
Pages (from-to)1583-1596
Number of pages14
JournalIEEE Transactions on Network Science and Engineering
Issue number3
Publication statusPublished - 1 Jul 2020


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