Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

SVIN COVID-19 Global Stroke Registry

doi:10.1212/WNL.0000000000011885

Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

SVIN COVID-19 Global Stroke Registry

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Abstract

OBJECTIVE: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.

METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.

RESULTS: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p

CONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.

Original language	English
Pages (from-to)	e2824 - e2838
Number of pages	15
Journal	Neurology
Volume	96
Issue number	23
DOIs	https://doi.org/10.1212/WNL.0000000000011885
Publication status	Published - 8 Jun 2021

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10.1212/WNL.0000000000011885

Nogueira et al., 2021 Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis Accepted author manuscript, 4.1 MB

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@article{a00855574ca84ec7b687cc43a34f9be5,

title = "Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis",

abstract = "OBJECTIVE: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.RESULTS: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, pCONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.",

author = "{SVIN COVID-19 Global Stroke Registry} and Nogueira, {Raul G} and Qureshi, {Muhammed M} and Mohamad Abdalkader and Martins, {Sheila Ouriques} and Hiroshi Yamagami and Zhongming Qiu and Mansour, {Ossama Yassin} and Anvitha Sathya and Anna Czlonkowska and Georgios Tsivgoulis and {Aguiar de Sousa}, Diana and Jelle Demeestere and Robert Mikulik and Peter Vanacker and Siegler, {James E} and Janika K{\~o}rv and Jose Biller and Liang, {Conrad W} and Sangha, {Navdeep S} and Zha, {Alicia M} and Czap, {Alexandra L} and Holmstedt, {Christine Anne} and Turan, {Tanya N} and George Ntaios and Konark Malhotra and Ashis Tayal and Aaron Loochtan and Annamarei Ranta and Mistry, {Eva A} and Alexandrov, {Anne W} and Huang, {David Y} and Shadi Yaghi and Eytan Raz and Sheth, {Sunil A} and Mohammaden, {Mahmoud H} and Michael Frankel and {Bila Lamou}, {Eric Guemekane} and Aref, {Hany M} and Ahmed Elbassiouny and Farouk Hassan and Tarek Menecie and Wessam Mustafa and Shokri, {Hossam M} and Tamer Roushdy and Sarfo, {Fred S} and Alabi, {Tolulope Oyetunde} and Babawale Arabambi and Nwazor, {Ernest O} and Sunmonu, {Taofiki Ajao} and Kolawole Wahab and Joseph Yaria and Mohammed, {Haytham Hussein} and Adebayo, {Philip B} and Riahi, {Anis D} and {Ben Sassi}, Samia and Lenon Gwaunza and Ngwende, {Gift Wilson} and David Sahakyan and Aminur Rahman and Zhibing Ai and Fanghui Bai and Zhenhui Duan and Yonggang Hao and Wenguo Huang and Guangwen Li and Wei Li and Ganzhe Liu and Jun Luo and Xianjin Shang and Yi Sui and Ling Tian and Hongbin Wen and Bo Wu and Yuying Yan and Zhengzhou Yuan and Hao Zhang and Jun Zhang and Wenlong Zhao and Wenjie Zi and Leung, {Thomas W} and Chandril Chugh and Vikram Huded and Bindu Menon and Sylaja, {P N} and Usman, {Fritz Sumantri} and Mehdi Farhoudi and Hokmabadi, {Elyar Sadeghi} and Anat Horev and Anna Reznik and Hoffmann, {Rotem Sivan} and Nobuyuki Ohara and Nobuyuki Sakai and Daisuke Watanabe and Ryoo Yamamoto and Ryosuke Doijiri and Naoki Tokuda and Takehiro Yamada and Tadashi Terasaki and Yukako Yazawa and Takeshi Uwatoko and Tomohisa Dembo and Hisao Shimizu and Yuri Sugiura and Fumio Miyashita and Hiroki Fukuda and Kosuke Miyake and Junsuke Shimbo and Yusuke Sugimura and Yoshiki Yagita and Yohei Takenobu and Yuji Matsumaru and Satoshi Yamada and Ryuhei Kono and Takuya Kanamaru and Hidekazu Yamazaki and Manabu Sakaguchi and Kenichi Todo and Nobuaki Yamamoto and Kazutaka Sonoda and Tomoko Yoshida and Hiroyuki Hashimoto and Ichiro Nakahara and Aida Kondybayeva and Kamila Faizullina and Saltanat Kamenova and Murat Zhanuzakov and Jang-Hyun Baek and Yangha Hwang and Lee, {Jin Soo} and Lee, {Si Baek} and Jusun Moon and Hyungjong Park and Seo, {Jung Hwa} and Kwon-Duk Seo and Sohn, {Sung Il} and Young, {Chang Jun} and Rechdi Ahdab and {Wan Zaidi}, {Wan Asyraf} and Aziz, {Zariah Abdul} and Basri, {Hamidon Bin} and Chung, {Law Wan} and Ibrahim, {Aznita Binti} and Ibrahim, {Khairul Azmi} and Irene Looi and Tan, {Wee Yong} and Yahya, {Nafisah Wan} and Stanislav Groppa and Pavel Leahu and {Al Hashmi}, {Amal M} and Imam, {Yahia Zakaria} and Naveed Akhtar and Pineda-Franks, {Maria Carissa} and Co, {Christian Oliver} and Dmitriy Kandyba and Adel Alhazzani and Hosam Al-Jehani and Tham, {Carol Huilian} and Mamauag, {Marlie Jane} and Narayanaswamy Venketasubramanian and Chih-Hao Chen and Sung-Chun Tang and Anchalee Churojana and Esref Akil and Ozlem Ayka{\c c} and Ozdemir, {Atilla Ozcan} and Semih Giray and Hussain, {Syed Irteza} and Seby John and {Le Vu}, Huynh and Tran, {Anh Duc} and Nguyen, {Huy Hoang} and Pham, {Thong Nhu} and Nguyen, {Thang Huy} and Nguyen, {Trung Quoc} and Thomas Gattringer and Christian Enzinger and Monika Killer-Oberpfalzer and Flavio Bellante and {De Blauwe}, Sofie and Geert Vanhooren and {De Raedt}, Sylvie and Anne Dusart and Robin Lemmens and Noemie Ligot and Rutgers, {Matthieu Pierre} and Laetitia Yperzeele and Filip Alexiev and Teodora Sakelarova and Bedekovi{\'c}, {Marina Roje} and Hrvoje Budincevic and Igor Cindri{\'c} and Zlatko Hucika and David Ozretic and Saric, {Majda Seferovic} and Frantiek Pfeifer and Igor Karpowic and David Cernik and Martin Sramek and Miroslav Skoda and Helena Hlavacova and Lukas Klecka and Martin Koutny and Daniel Vaclavik and Ondrej Skoda and Jan Fiksa and Katerina Hanelova and Miroslava Nevsimalova and Robert Rezek and Petr Prochazka and Gabriela Krejstova and Jiri Neumann and Marta Vachova and Henryk Brzezanski and David Hlinovsky and Dusan Tenora and Rene Jura and Lubom{\'i}r Jur{\'a}k and Jan Novak and Ales Novak and Zdenek Topinka and Petr Fibrich and Helena Sobolova and Ondrej Volny and Christensen, {Hanne Krarup} and Nicolas Drenck and Iversen, {Helle Klingenberg} and Simonsen, {Claus Z} and Truelsen, {Thomas Clement} and Troels Wienecke and Riina Vibo and Katrin Gross-Paju and Toomas Toomsoo and Katrin Antsov and Francois Caparros and Charlotte Cordonnier and Maria Dan and Jean-Marc Faucheux and Laura Mechtouff and Omer Eker and Emilie Lesaine and Basile Ondze and Roxane Peres and Hill, {Michael D} and Morris, {Jane G} and Romero, {Jose Rafael} and Abhishek Singh and Bruce Campbell and Hankey, {Graeme J} and Nguyen, {Thanh N}",

year = "2021",

month = jun,

day = "8",

doi = "10.1212/WNL.0000000000011885",

language = "English",

volume = "96",

pages = "e2824 -- e2838",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams & Wilkins",

number = "23",

}

TY - JOUR

T1 - Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

AU - SVIN COVID-19 Global Stroke Registry

AU - Nogueira, Raul G

AU - Qureshi, Muhammed M

AU - Abdalkader, Mohamad

AU - Martins, Sheila Ouriques

AU - Yamagami, Hiroshi

AU - Qiu, Zhongming

AU - Mansour, Ossama Yassin

AU - Sathya, Anvitha

AU - Czlonkowska, Anna

AU - Tsivgoulis, Georgios

AU - Aguiar de Sousa, Diana

AU - Demeestere, Jelle

AU - Mikulik, Robert

AU - Vanacker, Peter

AU - Siegler, James E

AU - Kõrv, Janika

AU - Biller, Jose

AU - Liang, Conrad W

AU - Sangha, Navdeep S

AU - Zha, Alicia M

AU - Czap, Alexandra L

AU - Holmstedt, Christine Anne

AU - Turan, Tanya N

AU - Ntaios, George

AU - Malhotra, Konark

AU - Tayal, Ashis

AU - Loochtan, Aaron

AU - Ranta, Annamarei

AU - Mistry, Eva A

AU - Alexandrov, Anne W

AU - Huang, David Y

AU - Yaghi, Shadi

AU - Raz, Eytan

AU - Sheth, Sunil A

AU - Mohammaden, Mahmoud H

AU - Frankel, Michael

AU - Bila Lamou, Eric Guemekane

AU - Aref, Hany M

AU - Elbassiouny, Ahmed

AU - Hassan, Farouk

AU - Menecie, Tarek

AU - Mustafa, Wessam

AU - Shokri, Hossam M

AU - Roushdy, Tamer

AU - Sarfo, Fred S

AU - Alabi, Tolulope Oyetunde

AU - Arabambi, Babawale

AU - Nwazor, Ernest O

AU - Sunmonu, Taofiki Ajao

AU - Wahab, Kolawole

AU - Yaria, Joseph

AU - Mohammed, Haytham Hussein

AU - Adebayo, Philip B

AU - Riahi, Anis D

AU - Ben Sassi, Samia

AU - Gwaunza, Lenon

AU - Ngwende, Gift Wilson

AU - Sahakyan, David

AU - Rahman, Aminur

AU - Ai, Zhibing

AU - Bai, Fanghui

AU - Duan, Zhenhui

AU - Hao, Yonggang

AU - Huang, Wenguo

AU - Li, Guangwen

AU - Li, Wei

AU - Liu, Ganzhe

AU - Luo, Jun

AU - Shang, Xianjin

AU - Sui, Yi

AU - Tian, Ling

AU - Wen, Hongbin

AU - Wu, Bo

AU - Yan, Yuying

AU - Yuan, Zhengzhou

AU - Zhang, Hao

AU - Zhang, Jun

AU - Zhao, Wenlong

AU - Zi, Wenjie

AU - Leung, Thomas W

AU - Chugh, Chandril

AU - Huded, Vikram

AU - Menon, Bindu

AU - Sylaja, P N

AU - Usman, Fritz Sumantri

AU - Farhoudi, Mehdi

AU - Hokmabadi, Elyar Sadeghi

AU - Horev, Anat

AU - Reznik, Anna

AU - Hoffmann, Rotem Sivan

AU - Ohara, Nobuyuki

AU - Sakai, Nobuyuki

AU - Watanabe, Daisuke

AU - Yamamoto, Ryoo

AU - Doijiri, Ryosuke

AU - Tokuda, Naoki

AU - Yamada, Takehiro

AU - Terasaki, Tadashi

AU - Yazawa, Yukako

AU - Uwatoko, Takeshi

AU - Dembo, Tomohisa

AU - Shimizu, Hisao

AU - Sugiura, Yuri

AU - Miyashita, Fumio

AU - Fukuda, Hiroki

AU - Miyake, Kosuke

AU - Shimbo, Junsuke

AU - Sugimura, Yusuke

AU - Yagita, Yoshiki

AU - Takenobu, Yohei

AU - Matsumaru, Yuji

AU - Yamada, Satoshi

AU - Kono, Ryuhei

AU - Kanamaru, Takuya

AU - Yamazaki, Hidekazu

AU - Sakaguchi, Manabu

AU - Todo, Kenichi

AU - Yamamoto, Nobuaki

AU - Sonoda, Kazutaka

AU - Yoshida, Tomoko

AU - Hashimoto, Hiroyuki

AU - Nakahara, Ichiro

AU - Kondybayeva, Aida

AU - Faizullina, Kamila

AU - Kamenova, Saltanat

AU - Zhanuzakov, Murat

AU - Baek, Jang-Hyun

AU - Hwang, Yangha

AU - Lee, Jin Soo

AU - Lee, Si Baek

AU - Moon, Jusun

AU - Park, Hyungjong

AU - Seo, Jung Hwa

AU - Seo, Kwon-Duk

AU - Sohn, Sung Il

AU - Young, Chang Jun

AU - Ahdab, Rechdi

AU - Wan Zaidi, Wan Asyraf

AU - Aziz, Zariah Abdul

AU - Basri, Hamidon Bin

AU - Chung, Law Wan

AU - Ibrahim, Aznita Binti

AU - Ibrahim, Khairul Azmi

AU - Looi, Irene

AU - Tan, Wee Yong

AU - Yahya, Nafisah Wan

AU - Groppa, Stanislav

AU - Leahu, Pavel

AU - Al Hashmi, Amal M

AU - Imam, Yahia Zakaria

AU - Akhtar, Naveed

AU - Pineda-Franks, Maria Carissa

AU - Co, Christian Oliver

AU - Kandyba, Dmitriy

AU - Alhazzani, Adel

AU - Al-Jehani, Hosam

AU - Tham, Carol Huilian

AU - Mamauag, Marlie Jane

AU - Venketasubramanian, Narayanaswamy

AU - Chen, Chih-Hao

AU - Tang, Sung-Chun

AU - Churojana, Anchalee

AU - Akil, Esref

AU - Aykaç, Ozlem

AU - Ozdemir, Atilla Ozcan

AU - Giray, Semih

AU - Hussain, Syed Irteza

AU - John, Seby

AU - Le Vu, Huynh

AU - Tran, Anh Duc

AU - Nguyen, Huy Hoang

AU - Pham, Thong Nhu

AU - Nguyen, Thang Huy

AU - Nguyen, Trung Quoc

AU - Gattringer, Thomas

AU - Enzinger, Christian

AU - Killer-Oberpfalzer, Monika

AU - Bellante, Flavio

AU - De Blauwe, Sofie

AU - Vanhooren, Geert

AU - De Raedt, Sylvie

AU - Dusart, Anne

AU - Lemmens, Robin

AU - Ligot, Noemie

AU - Rutgers, Matthieu Pierre

AU - Yperzeele, Laetitia

AU - Alexiev, Filip

AU - Sakelarova, Teodora

AU - Bedeković, Marina Roje

AU - Budincevic, Hrvoje

AU - Cindrić, Igor

AU - Hucika, Zlatko

AU - Ozretic, David

AU - Saric, Majda Seferovic

AU - Pfeifer, Frantiek

AU - Karpowic, Igor

AU - Cernik, David

AU - Sramek, Martin

AU - Skoda, Miroslav

AU - Hlavacova, Helena

AU - Klecka, Lukas

AU - Koutny, Martin

AU - Vaclavik, Daniel

AU - Skoda, Ondrej

AU - Fiksa, Jan

AU - Hanelova, Katerina

AU - Nevsimalova, Miroslava

AU - Rezek, Robert

AU - Prochazka, Petr

AU - Krejstova, Gabriela

AU - Neumann, Jiri

AU - Vachova, Marta

AU - Brzezanski, Henryk

AU - Hlinovsky, David

AU - Tenora, Dusan

AU - Jura, Rene

AU - Jurák, Lubomír

AU - Novak, Jan

AU - Novak, Ales

AU - Topinka, Zdenek

AU - Fibrich, Petr

AU - Sobolova, Helena

AU - Volny, Ondrej

AU - Christensen, Hanne Krarup

AU - Drenck, Nicolas

AU - Iversen, Helle Klingenberg

AU - Simonsen, Claus Z

AU - Truelsen, Thomas Clement

AU - Wienecke, Troels

AU - Vibo, Riina

AU - Gross-Paju, Katrin

AU - Toomsoo, Toomas

AU - Antsov, Katrin

AU - Caparros, Francois

AU - Cordonnier, Charlotte

AU - Dan, Maria

AU - Faucheux, Jean-Marc

AU - Mechtouff, Laura

AU - Eker, Omer

AU - Lesaine, Emilie

AU - Ondze, Basile

AU - Peres, Roxane

AU - Hill, Michael D

AU - Morris, Jane G

AU - Romero, Jose Rafael

AU - Singh, Abhishek

AU - Campbell, Bruce

AU - Hankey, Graeme J

AU - Nguyen, Thanh N

PY - 2021/6/8

Y1 - 2021/6/8

N2 - OBJECTIVE: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.RESULTS: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, pCONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.

AB - OBJECTIVE: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods.METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases.RESULTS: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, pCONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.

UR - http://www.scopus.com/inward/record.url?scp=85106084873&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000011885

DO - 10.1212/WNL.0000000000011885

M3 - Article

C2 - 33766997

SN - 0028-3878

VL - 96

SP - e2824 - e2838

JO - Neurology

JF - Neurology

IS - 23

ER -

Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

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