Global eligibility and cost effectiveness of icosapent ethyl in primary and secondary cardiovascular prevention

Peter P Toth, Jean Ferrières, Max Waters, Martin Bødtker Mortensen, Nick S R Lan, Nathan D Wong

Research output: Contribution to journalReview articlepeer-review

Abstract

Icosapent ethyl (IPE) is a purified eicosapentaenoic acid-only omega-3 fatty acid that significantly reduced cardiovascular (CV) events in patients receiving statins with established cardiovascular disease (CVD) and those with diabetes and additional risk factors in the pivotal REDUCE-IT trial. Since the publication of REDUCE-IT, there has been global interest in determining IPE eligibility in different patient populations, the proportion of patients who may benefit from IPE, and cost effectiveness of IPE in primary and secondary prevention settings. The aim of this review is to summarize information from eligibility and cost effectiveness studies of IPE to date. A total of sixteen studies were reviewed, involving 2,068,111 patients in the primary or secondary prevention settings worldwide. Up to forty-five percent of patients were eligible for IPE, depending on the selection criteria used (ie, REDUCE-IT criteria, US Food and Drug Administration label, Health Canada label, practice guidelines) and the population studied. Overall, eight cost-effectiveness studies across the United States, Canada, Germany, Israel, and Australia were included in this review and findings indicated that IPE is particularly cost effective in patients with established CVD.

Original languageEnglish
Article number1220017
Number of pages13
JournalFrontiers in Cardiovascular Medicine
Volume10
DOIs
Publication statusPublished - 2023

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