Global challenges in the development and delivery of paediatric antiretrovirals

Asha Bowen, Pamela Palasanthiran, Annette H Sohn

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


By the end of 2006, compared with 28% coverage for adults, only 15% of children with HIV that needed antiretroviral treatment were receiving it. Major challenges in delivering treatment include the lack of paediatric antiretrovirals that can be dosed in small children and limited studies examining safety and efficacy for existing antiretroviral formulations. The high costs of treatment have been reduced through the use of generic, fixed-dose combination drugs. Evidence-based strategies for managing resistance and the scale-up of pharmacological trials for children in low- and middle-income countries are crucial to the success and future development of paediatric antiretrovirals.

Original languageEnglish
Pages (from-to)530-5
Number of pages6
JournalDrug Discovery Today
Issue number11-12
Publication statusPublished - Jun 2008
Externally publishedYes


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