TY - JOUR
T1 - GISCOME - Genetics of Ischaemic Stroke Functional Outcome network
T2 - A protocol for an international multicentre genetic association study
AU - Int Stroke Genetics Consortium
AU - NINDS-SiGN Consortium
AU - Maguire, Jane M.
AU - Bevan, Steve
AU - Stanne, Tara M.
AU - Lorenzen, Erik
AU - Fernandez-Cadenas, Israel
AU - Hankey, Graeme J.
AU - Jimenez-Conde, Jordi
AU - Jood, Katarina
AU - Lee, Jin-Moo
AU - Lemmens, Robin
AU - Levi, Christopher
AU - Norrving, Bo
AU - Rannikmae, Kristiina
AU - Rost, Natalia
AU - Rosand, Jonathan
AU - Rothwell, Peter M.
AU - Scott, Rodney
AU - Strbian, Daniel
AU - Sturm, Jonathan
AU - Sudlow, Cathie
AU - Traylor, Matthew
AU - Thijs, Vincent
AU - Tatlisumak, Turgut
AU - Wieloch, Tadeusz
AU - Woo, Daniel
AU - Worrall, Bradford B.
AU - Jern, Christina
AU - Lindgren, Arne
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Introduction: Genome-wide association studies have identified several novel genetic loci associated with stroke risk, but how genetic factors influence stroke outcome is less studied. The Genetics of Ischaemic Stroke Functional outcome network aims at performing genetic studies of stroke outcome. We here describe the study protocol and methods basis of Genetics of Ischaemic Stroke Functional outcome.Methods: The Genetics of Ischaemic Stroke Functional outcome network has assembled patients from 12 ischaemic stroke projects with genome-wide genotypic and outcome data from the International Stroke Genetics Consortium and the National Institute of Neurological Diseases Stroke Genetics Network initiatives. We have assessed the availability of baseline variables, outcome metrics and time-points for collection of outcome data.Results: We have collected 8831 ischaemic stroke cases with genotypic and outcome data. Modified Rankin score was the outcome metric most readily available. We detected heterogeneity between cohorts for age and initial stroke severity (according to the NIH Stroke Scale), and will take this into account in analyses. We intend to conduct a first phase genome-wide association outcome study on ischaemic stroke cases with data on initial stroke severity and modified Rankin score within 60-190 days. To date, we have assembled 5762 such cases and are currently seeking additional cases meeting these criteria for second phase analyses.Conclusion: Genetics of Ischaemic Stroke Functional outcome is a unique collection of ischaemic stroke cases with detailed genetic and outcome data providing an opportunity for discovery of genetic loci influencing functional outcome. Genetics of Ischaemic Stroke Functional outcome will serve as an exploratory study where the results as well as the methodological observations will provide a basis for future studies on functional outcome. Genetics of Ischaemic Stroke Functional outcome can also be used for candidate gene replication or assessing stroke outcome non-genetic association hypotheses.
AB - Introduction: Genome-wide association studies have identified several novel genetic loci associated with stroke risk, but how genetic factors influence stroke outcome is less studied. The Genetics of Ischaemic Stroke Functional outcome network aims at performing genetic studies of stroke outcome. We here describe the study protocol and methods basis of Genetics of Ischaemic Stroke Functional outcome.Methods: The Genetics of Ischaemic Stroke Functional outcome network has assembled patients from 12 ischaemic stroke projects with genome-wide genotypic and outcome data from the International Stroke Genetics Consortium and the National Institute of Neurological Diseases Stroke Genetics Network initiatives. We have assessed the availability of baseline variables, outcome metrics and time-points for collection of outcome data.Results: We have collected 8831 ischaemic stroke cases with genotypic and outcome data. Modified Rankin score was the outcome metric most readily available. We detected heterogeneity between cohorts for age and initial stroke severity (according to the NIH Stroke Scale), and will take this into account in analyses. We intend to conduct a first phase genome-wide association outcome study on ischaemic stroke cases with data on initial stroke severity and modified Rankin score within 60-190 days. To date, we have assembled 5762 such cases and are currently seeking additional cases meeting these criteria for second phase analyses.Conclusion: Genetics of Ischaemic Stroke Functional outcome is a unique collection of ischaemic stroke cases with detailed genetic and outcome data providing an opportunity for discovery of genetic loci influencing functional outcome. Genetics of Ischaemic Stroke Functional outcome will serve as an exploratory study where the results as well as the methodological observations will provide a basis for future studies on functional outcome. Genetics of Ischaemic Stroke Functional outcome can also be used for candidate gene replication or assessing stroke outcome non-genetic association hypotheses.
KW - Genetic association studies
KW - stroke
KW - functional outcome
KW - GENOME-WIDE ASSOCIATION
KW - MODIFIED RANKIN SCALE
KW - CAUSATIVE CLASSIFICATION
KW - GLOBAL BURDEN
KW - RECOVERY
KW - BRAIN
KW - RISK
KW - POLYMORPHISMS
KW - HERITABILITY
KW - METAANALYSIS
U2 - 10.1177/2396987317704547
DO - 10.1177/2396987317704547
M3 - Article
SN - 2396-9873
VL - 2
SP - 229
EP - 237
JO - European stroke journal
JF - European stroke journal
IS - 3
ER -