© 2015 Elsevier B.V.. This paper reports a deposit-scale GIS-based 3D mineral potential assessment of the Jiama copper-polymetallic deposit in Tibet, China. The assessment was achieved through a sequential implementation of metallogenic modelling and 3D modelling of geology, geochemistry and prospectivity. A metallogenic model for the Jiama deposit and 3D modelling workflow were used to construct multiple 3D layers of volumetric and triangular mesh models to represent geology, geochemistry and ore-controlling features in the study area. A GIS-based 3D weights-of-evidence analysis was then used to estimate the subsurface prospectivity for Cu (Mo) orebodies in the area, which led to the identification of three prospective deep-seated exploration targets. Additionally, the geochemical modelling indicates three potential fluid flow pathways based on the 3D zonation of major geochemical elements and their ratios, particularly the Zn/Pb ratios, which support the results of the weights of evidence model.