TY - JOUR
T1 - Ghrelin and peptide YY Change during Puberty
T2 - Relationships with adolescent growth, development, and obesity
AU - Cheng, Hoi Lun
AU - Sainsbury, Amanda
AU - Garden, Frances
AU - Sritharan, Myuran
AU - Paxton, Karen
AU - Luscombe, Georgina
AU - Hawke, Catherine
AU - Steinbeck, Katharine
N1 - Funding Information:
Financial Support: This work was supported by a joint Sydney Medical School and Balnaves Foundation Kick Start Grant (to H.L.C.), a Sydney Medical School Lifespan Seed Grant (to H.L.C.), the National Health and Medical Research Council of Australia (to K.S.) and the Thyne Reid Foundation (to K.S.).
Publisher Copyright:
© 2018 Endocrine Society.
PY - 2018
Y1 - 2018
N2 - Context: Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective: To measure ghrelin and PYY change in relation to pubertal growth. Design: Three-year prospective cohort study. Setting: Australian regional community. Participants: Eighty healthy adolescents (26 girls; 54 boys) recruited at 10 to 13 years. Main Outcome Measures: Fasting circulating total ghrelin, total PYY, IGF-1, insulin, leptin (via radioimmunoassay), estradiol and testosterone (via mass spectrometry), anthropometry, and body composition (via bioelectrical impedance). Results: Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age 2 (both sexes: P < 0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: P < 0.05), leptin in girls (P < 0.01), and insulin in boys (P < 0.05) and negatively correlated with annual height and weight velocity (both sexes: P ≤ 0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age 2 in healthy-weight but not overweight and obese adolescents (7 girls; 18 boys). Conclusions: Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The overweight and obesity subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and longterm metabolic risk.
AB - Context: Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective: To measure ghrelin and PYY change in relation to pubertal growth. Design: Three-year prospective cohort study. Setting: Australian regional community. Participants: Eighty healthy adolescents (26 girls; 54 boys) recruited at 10 to 13 years. Main Outcome Measures: Fasting circulating total ghrelin, total PYY, IGF-1, insulin, leptin (via radioimmunoassay), estradiol and testosterone (via mass spectrometry), anthropometry, and body composition (via bioelectrical impedance). Results: Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age 2 (both sexes: P < 0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: P < 0.05), leptin in girls (P < 0.01), and insulin in boys (P < 0.05) and negatively correlated with annual height and weight velocity (both sexes: P ≤ 0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age 2 in healthy-weight but not overweight and obese adolescents (7 girls; 18 boys). Conclusions: Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The overweight and obesity subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and longterm metabolic risk.
UR - http://www.scopus.com/inward/record.url?scp=85055119379&partnerID=8YFLogxK
U2 - 10.1210/jc.2017-01825
DO - 10.1210/jc.2017-01825
M3 - Article
C2 - 29860506
AN - SCOPUS:85055119379
SN - 0021-972X
VL - 103
SP - 2851
EP - 2860
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 8
ER -
