The Cambro-Ordovician Glenelg River Complex in the Harrow district, western Victoria, consists of extensive granitic rocks associated with a migmatitic metasedimentary envelope. Metasedimentary rocks comprise amphibolite facies massive-laminated quartzo-feldspathic schists and layered gneisses with minor sillimanite-bearing horizons. Intercalated are stromatic and nebulitic migmatites of granitic and tonalitic character; textural evidence suggests that both varieties developed by in situ partial melting. Ranging from adamellite to leucotonalite, granitic rocks contain abundant magmatic muscovite, commonly with garnet and sillimanite, and exhibit generally unrecrystallised igneous textures. Heterogeneous structurally concordant plutons transitional to migmatites and more uniform intrusive phases are delineated with both types hosting diverse metasedimentary enclaves, micaceous selvages and schlieren; a gneissic foliation of variable intensity is defined by the latter. These petrographic attributes are consistent with derivation of plutons by anatexis of a peraluminous metasedimentary protolith. The schlieric foliation is not tectonically imposed, but rather directly inherited from the migmatitic precursor, compositional variations within which are preserved by the layered Schofield Adamellite. The most mafic granitic body (Tuloona Granodiorite) also has igneous microgranular enclaves indicating a more complex petrogenesis. Metasedimentary rocks experienced five episodes of folding, the latest involving macroscopic open warps. This is analogous to the structural history elucidated elsewhere in the Glenelg River Complex, by inference a coherent tectonic entity whose present metamorphic and stratigraphic configuration might be governed by F5 folding. Structures within migmatites intimate that partial melting proceeded throughout the deformational history and peaked syn-D4 to pre-D5, whilst temperatures had waned to sub-biotite grade in the southwestern Glenelg River Complex. Granitic rocks were generated during this anatectic culmination and were therefore emplaced late in the orogenic history relative to other syntectonic phases of the Glenelg River Complex.