Geogenic PM10 exposure exacerbates responses to influenza infection

H.D. Clifford, Kara Perks, Graeme Zosky

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

© 2015. Particulate matter (PM) exposure has been linked epidemiologically to exacerbations of lung disease, including respiratory infections. We investigated the effects of geogenic (earth-derived) PM10 (PM10 (10μg/day for 10days), and/or infected with influenza (A/Mem/1/71) virus. Inflammation (cells, IL-6, IFN-γ) was measured in bronchoalveolar lavage. Lung mechanics were measured using the forced oscillation technique.Geogenic PM10 induced lung inflammation (neutrophils, macrophages) with additive effects in mice also infected with influenza. PM10 also modified the influenza-induced IL-6 and IFN-γ responses. Geogenic PM10 increased airway resistance, and increased hysteresivity in those exposed to both insults. Viral titres were significantly higher after PM10 exposure. Iron concentration was inversely associated with IFN-γ and positively associated with viral titre and hysteresivity.Geogenic PM10 exposure increases inflammation, impairs lung function and increases viral load, exacerbating the response to respiratory viral infection. Iron in the particles may be a driver of these responses. This has important implications for respiratory health in communities exposed to high geogenic PM10, such as those in arid environments.
Original languageEnglish
Pages (from-to)275-282
Number of pages8
JournalScience of the Total Environment
Volume533
DOIs
Publication statusPublished - 2015

Fingerprint

Dive into the research topics of 'Geogenic PM10 exposure exacerbates responses to influenza infection'. Together they form a unique fingerprint.

Cite this