Genomics-Driven Discovery and Biosynthesis of Bioactive Small Molecules from Fungi

Hang Li

Research output: ThesisDoctoral Thesis

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Abstract

Fungal genomes encode vast potential for biosynthesis of myriad bioactive small molecules. By mining the genome of the damaging wheat pathogen Parastagonospora nodorum, three biosynthetic gene clusters phm, alp and sth were revealed to encode the production of phytotoxic molecules phomacins, alternapyrones and stemphyloxins, respectively. Phomacins were shown to be involved in virulence. The elucidation of the biosynthesis of two novel alkaloids, burnettramic acid and nanangelenin A, from two novel Australian Aspergillus fungi was also described. The thesis contributed to new knowledge on fungal secondary metabolism and opened up opportunities to harness the molecules and enzymes for biotechnological applications.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Chooi, Heng, Supervisor
  • Stubbs, Keith, Supervisor
Thesis sponsors
Award date3 Jun 2020
DOIs
Publication statusUnpublished - 2020

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