Genomic Profiling and Monitoring in Acute Myeloid Leukaemia using Plasma cell-free DNA

Hun Chuah

Research output: ThesisDoctoral Thesis

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Abstract

This study examined the suitability of cell-free DNA (cfDNA) (urine and plasma) for molecular assessment of Acute Myeloid Leukaemia (AML). Plasma cfDNA was found to be the optimal sample and was used to analyse mutations and fractional burden in blood from adult patients with AML. Plasma cfDNA levels correlated with the current gold standard (i.e. bone marrow) to a limit of 0.11%. cfDNA accurately reflected the mutational burden changes seen in response to therapy and outcome (i.e. remission, refractory disease, relapse). Plasma cfDNA is minimally invasive and suitable for regular assessment of leukaemic burden at levels that are clinical significant.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Erber, Wendy, Supervisor
  • Guo, Belinda, Supervisor
  • Leahy, Michael, Supervisor
  • Allcock, Richard, Supervisor
Thesis sponsors
Award date7 Jun 2022
DOIs
Publication statusUnpublished - 2022

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